INT81761

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Context Info
Confidence 0.55
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 8.48
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
ETT 1
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 280 100.00 Very High Very High Very High
dexamethasone 128 99.84 Very High Very High Very High
Analgesic 35 99.32 Very High Very High Very High
Inflammation 129 98.52 Very High Very High Very High
Pain 115 98.32 Very High Very High Very High
cINOD 2 97.56 Very High Very High Very High
hyperexcitability 14 95.76 Very High Very High Very High
Hyperalgesia 21 90.48 High High
tolerance 14 89.36 High High
substance P 63 88.88 High High
Disease Link Frequency Relevance Heat
Pharyngitis 156 100.00 Very High Very High Very High
Stress 81 100.00 Very High Very High Very High
Pancreatitis 14 100.00 Very High Very High Very High
Disease 14 98.68 Very High Very High Very High
INFLAMMATION 143 98.52 Very High Very High Very High
Injury 20 96.84 Very High Very High Very High
Pain 101 96.72 Very High Very High Very High
Nociception 70 95.08 Very High Very High Very High
Hoarseness 36 94.16 High High
Cough 32 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
conceivable that the reduction of POP activity participates in the development
Negative_regulation (reduction) of POP
1) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.50 Pain Relevance 0.55
Alternatively, only the reduction of POP activity below a critical level, as
Negative_regulation (reduction) of POP
2) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.41 Pain Relevance 0.74
effect on DPPIV activity, but produced a reduction on POP activity levels in
Negative_regulation (reduction) of POP
3) Confidence 0.55 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.39 Pain Relevance 0.09
resulted in a drop of POP activity levels (0.79-fold) in the TGE
Negative_regulation (drop) of POP
4) Confidence 0.40 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.14
This study aims to analyze the interference of MTX and CsA, each one daily administered alone or combined during 21 days, on the activity levels of S DPPIV and POP, and MDPPIV in two distinct status of ex
Spec (analyze) Negative_regulation (interference) of POP associated with methotrexate
5) Confidence 0.40 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 1.02 Pain Relevance 0.67
resulted in a drop of POP activity levels (0.79-fold) in the TGE
Negative_regulation (drop) of POP
6) Confidence 0.40 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.19
Prevention of PEP includes administration of nonsteroidal inflammatory drugs (NSAIDs), use of specific cannulation techniques, and placement of temporary pancreatic stents.
Negative_regulation (Prevention) of PEP associated with inflammation, pancreatitis and cinod
7) Confidence 0.37 Published 2010 Journal Endoscopy Section Abstract Doc Link 20506068 Disease Relevance 0.65 Pain Relevance 0.15
The aim of this guideline commissioned by the European Society of Gastrointestinal Endoscopy (ESGE) is to provide practical, graded, recommendations for the prevention of PEP.
Negative_regulation (prevention) of PEP associated with pancreatitis
8) Confidence 0.37 Published 2010 Journal Endoscopy Section Abstract Doc Link 20506068 Disease Relevance 0.67 Pain Relevance 0.13
s, methotrexate increased DPPIV (99–110%) and POP (60%), while cyclosporine inhibited POP (21%).
Negative_regulation (inhibited) of POP associated with methotrexate
9) Confidence 0.35 Published 2008 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2266974 Disease Relevance 0.07 Pain Relevance 0.32
CONCLUSIONS: Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST.


Negative_regulation (reduce) of POST in ETT
10) Confidence 0.35 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20304980 Disease Relevance 0 Pain Relevance 0
Our data demonstrate that blocking Erk activation with a small molecule inhibitor prior to PE stress blocks the previously observed increase in myostatin expression.
Negative_regulation (blocks) of PE associated with stress
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2856679 Disease Relevance 1.09 Pain Relevance 0
Therefore, the prevention of POST is an important issue.
Negative_regulation (prevention) of POST associated with pharyngitis
12) Confidence 0.08 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 0.86 Pain Relevance 0.56
Although previous studies have demonstrated the efficacy of dexamethasone for the prevention of POST after tracheal intubation, the present study was performed to investigate the influence of administration time.
Negative_regulation (prevention) of POST associated with pharyngitis and dexamethasone
13) Confidence 0.07 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 0.85 Pain Relevance 0.43
In previous studies that evaluated the effectiveness of dexamethasone in the prevention of POST after tracheal intubation, the preoperative administration of intravenous dexamethasone was compared with placebo.
Negative_regulation (prevention) of POST associated with pharyngitis and dexamethasone
14) Confidence 0.07 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 0.77 Pain Relevance 0.71
This study investigates the pharmacokinetics and safety profile of Z-321, (4R)-3-(indan-2-ylacetyl)-4-(1-pyrrolidinyl-carbonyl)-1,3-thiazoli dine, a novel specific orally active prolyl endopeptidase (PEP) inhibitor.
Negative_regulation (inhibitor) of PEP
15) Confidence 0.05 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 10234593 Disease Relevance 0 Pain Relevance 0
The sample size was estimated from preliminary data obtained from 50 patients and the assumption that a 50% reduction in the incidence of POST would be clinically relevant.
Negative_regulation (reduction) of POST associated with pharyngitis
16) Confidence 0.05 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872887 Disease Relevance 1.20 Pain Relevance 0.06

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