INT81766

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.57
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna2d2)
Cacna2d2 (Mus musculus)
Pain Link Frequency Relevance Heat
methadone 16 100.00 Very High Very High Very High
potassium channel 3 99.04 Very High Very High Very High
Potency 4 87.24 High High
lidocaine 1 86.76 High High
cva 2 46.40 Quite Low
Pain 4 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 39 100.00 Very High Very High Very High
Heart Rate Under Development 19 99.76 Very High Very High Very High
Atypical Pneumonia 2 99.48 Very High Very High Very High
Arrhythmias 2 Under Development 1 93.04 High High
Adverse Drug Reaction 4 85.16 High High
Cv General 2 Under Development 1 75.00 Quite High
Unconsciousness 4 66.24 Quite High
Hypertension 2 63.68 Quite High
Dementia 2 62.56 Quite High
Hemorrhage 2 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Cases of TdP associated with methadone have been reported to the FDA MedWatch system.
TdP Binding (associated) of
1) Confidence 0.23 Published 2005 Journal Pharmacoepidemiol Drug Saf Section Body Doc Link 15918160 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Q-T interval prolongation and TdP associated with the use of methadone are potentially fatal adverse effects.
TdP Binding (associated) of
2) Confidence 0.23 Published 2009 Journal Am J Health Syst Pharm Section Body Doc Link 19386945 Disease Relevance 0 Pain Relevance 0
This may suggest that potassium channel opening drugs are clinically effective against TdP associated with bradycardia-dependent QT prolongation.
TdP Binding (associated) of associated with heart rate under development and potassium channel
3) Confidence 0.20 Published 1999 Journal Pacing Clin Electrophysiol Section Abstract Doc Link 10234727 Disease Relevance 0.34 Pain Relevance 0.22
PURPOSE: The association of methadone with Q-T interval prolongation and torsades de pointes (TdP) is reviewed, and recommendations for preventing Q-T interval prolongation in methadone users are provided.
TdP Binding (association) of associated with arrhythmia under development and methadone
4) Confidence 0.20 Published 2009 Journal Am J Health Syst Pharm Section Abstract Doc Link 19386945 Disease Relevance 0.17 Pain Relevance 0.27
We then present a summary of the existing evidence base for methadone - associated TdP and offer guidance for the clinician on the need for cardiac screening of patients on methadone treatment.
TdP Binding (associated) of associated with methadone
5) Confidence 0.20 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630728 Disease Relevance 0 Pain Relevance 0.45
A wide variety of nonantiarrthymic medications may trigger TdP in patients with prolonged QT interval, only a few reports have described an association between TdP and methadone.
TdP Binding (association) of associated with arrhythmia under development and methadone
6) Confidence 0.16 Published 2004 Journal W V Med J Section Abstract Doc Link 15471174 Disease Relevance 0.64 Pain Relevance 0.27
Therefore it seems that the severe bradycardia assisted the development of TdP associated with these two moxifloxacin therapy.
TdP Binding (associated) of associated with heart rate under development and arrhythmia under development
7) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2621134 Disease Relevance 0.57 Pain Relevance 0.04
TdP associated with moxifloxacin have been reported in the extreme bradycardia patients who need cardiac pacemaker implantation [2,3].
TdP Binding (associated) of associated with heart rate under development and arrhythmia under development
8) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2621134 Disease Relevance 0.84 Pain Relevance 0

General Comments

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