INT81767

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Context Info
Confidence 0.23
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.70
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HTLVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.62 Very High Very High Very High
Dopamine 32 81.56 Quite High
opiate 1 70.24 Quite High
Catecholamine 8 60.40 Quite High
Neurotransmitter 8 57.28 Quite High
Spinal cord 4 38.40 Quite Low
medulla 4 36.80 Quite Low
adenocard 20 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 16 99.18 Very High Very High Very High
Infection 39 96.96 Very High Very High Very High
Viral Infection 4 95.64 Very High Very High Very High
Death 4 81.56 Quite High
Disease 16 79.20 Quite High
Epilepsy 4 76.80 Quite High
Schizophrenia 4 75.76 Quite High
Apoptosis 16 74.52 Quite High
Leukemia 9 72.48 Quite High
Stress 16 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that in an in vitro coinfection system (HIV-1 + HTLV-I), morphine treatment further enhanced the levels of HTLV-I p19.
Positive_regulation (enhanced) of Gene_expression (levels) of HTLV-I p19 associated with acquired immune deficiency syndrome or hiv infection and morphine
1) Confidence 0.23 Published 1999 Journal DNA Cell Biol. Section Abstract Doc Link 10235111 Disease Relevance 1.66 Pain Relevance 0.48
These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.
Positive_regulation (deregulated) of Gene_expression (expression) of HTLV3
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.04
These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.
Positive_regulation (deregulated) of Gene_expression (expression) of HTLV3
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.76 Pain Relevance 0
Glutathione was downregulated in HTLV3 transfected cells as well as HTLV1 transformed cells, indicating that downregulation of glutathione is a consequence of viral infection, not necessarily the transformation process.
Positive_regulation (transfected) of Gene_expression (transfected) of HTLV3 associated with viral infection
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.22 Pain Relevance 0.06
In fact, only two metabolites (spermidine and N-acetyl aspartic acid) were upregulated in both HTLV1 transformed and HTLV3 transfected cells.
Positive_regulation (upregulated) of Gene_expression (transformed) of HTLV3
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0.21

General Comments

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