INT81767

Context Info Confidence 0.23 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 5 Disease Relevance 2.70 Pain Relevance 0.78

HTLVR (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 5 99.62 Dopamine 32 81.56 opiate 1 70.24 Catecholamine 8 60.40 Neurotransmitter 8 57.28 Spinal cord 4 38.40 medulla 4 36.80 adenocard 20 5.00 Inflammation 8 5.00 imagery 8 5.00

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 16 99.18 Infection 39 96.96 Viral Infection 4 95.64 Death 4 81.56 Disease 16 79.20 Epilepsy 4 76.80 Schizophrenia 4 75.76 Apoptosis 16 74.52 Leukemia 9 72.48 Stress 16 71.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have found that in an in vitro coinfection system (HIV-1 + HTLV-I), morphine treatment further enhanced the levels of HTLV-I p19.

Positive_regulation (enhanced) of Gene_expression (levels) of HTLV-I p19 associated with acquired immune deficiency syndrome or hiv infection and morphine

1) Confidence 0.23 Published 1999 Journal DNA Cell Biol. Section Abstract Doc Link 10235111 Disease Relevance 1.66 Pain Relevance 0.48

These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.

Positive_regulation (deregulated) of Gene_expression (expression) of HTLV3

2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.04

These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.

Positive_regulation (deregulated) of Gene_expression (expression) of HTLV3

3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.76 Pain Relevance 0

Glutathione was downregulated in HTLV3 transfected cells as well as HTLV1 transformed cells, indicating that downregulation of glutathione is a consequence of viral infection, not necessarily the transformation process.

Positive_regulation (transfected) of Gene_expression (transfected) of HTLV3 associated with viral infection

4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.22 Pain Relevance 0.06

In fact, only two metabolites (spermidine and N-acetyl aspartic acid) were upregulated in both HTLV1 transformed and HTLV3 transfected cells.

Positive_regulation (upregulated) of Gene_expression (transformed) of HTLV3

5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0.21

General Comments

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