INT81768

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.97
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna4) transport (Chrna4) plasma membrane (Chrna4)
neurological system process (Chrna4)
Anatomy Link Frequency
neuronal 1
Chrna4 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 3 97.32 Very High Very High Very High
antagonist 1 93.64 High High
gABA 2 92.72 High High
Nicotine 10 92.48 High High
Pain 7 90.60 High High
Antinociceptive 6 83.68 Quite High
Analgesic 2 75.00 Quite High
antinociception 2 75.00 Quite High
tail-flick 1 74.48 Quite High
Central nervous system 3 71.52 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 8 97.84 Very High Very High Very High
Frontal Lobe Epilepsy 1 95.28 Very High Very High Very High
Benign Neonatal Epilepsy 1 92.80 High High
Pain 6 90.60 High High
Epilepsy 8 88.44 High High
Convulsion 18 86.08 High High
Partial Seizures 2 80.16 Quite High
Fever 2 71.64 Quite High
Anxiety Disorder 2 65.76 Quite High
Cognitive Disorder 5 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All of the study subjects molecularly characterized in this current report include loss of the gene group ARFGAP1, CHRNA4, and KCNQ2.
Negative_regulation (loss) of CHRNA4
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929201 Disease Relevance 1.14 Pain Relevance 0.03
To identify the functions of nicotinic or muscarinic acetylcholine receptor (nAChR or mAChR) subtypes, mice lacking beta 2 nAChR, alpha 4 nAChR, alpha 7 nAChR, M1 mAChR, and M2 mAChR have been generated.
Negative_regulation (lacking) of 4 nAChR
2) Confidence 0.38 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803206 Disease Relevance 0.14 Pain Relevance 0.10
To identify the particular subunits involved in this process, we generated mice lacking the alpha4 subunit of the neuronal nAChR by homologous recombination techniques and studied these together with previously generated mutant mice lacking the beta2 nAChR subunit.
Negative_regulation (lacking) of nAChR in neuronal
3) Confidence 0.32 Published 1999 Journal Nature Section Abstract Doc Link 10235262 Disease Relevance 0.09 Pain Relevance 0.60
To identify the functions of nicotinic or muscarinic acetylcholine receptor (nAChR or mAChR) subtypes, mice lacking beta 2 nAChR, alpha 4 nAChR, alpha 7 nAChR, M1 mAChR, and M2 mAChR have been generated.
Negative_regulation (lacking) of nAChR
4) Confidence 0.28 Published 1999 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 10803206 Disease Relevance 0.14 Pain Relevance 0.10
RT-PCR and western blot analysis confirmed the absence of the alpha9 nAChR in mice carrying a null mutation for the nAChR alpha9 gene.
Negative_regulation (absence) of alpha9 nAChR
5) Confidence 0.05 Published 2010 Journal Channels (Austin) Section Abstract Doc Link 20368690 Disease Relevance 0.46 Pain Relevance 0.37

General Comments

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