INT81774

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Context Info
Confidence 0.09
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.71
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
liver 1
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 92.24 High High
Inflammation 33 92.08 High High
Angina 6 90.20 High High
ischemia 9 84.44 Quite High
Paracetamol 2 75.00 Quite High
bradykinin 2 71.92 Quite High
Bioavailability 1 28.80 Quite Low
Bile 1 25.08 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spontaneous Abortion 2 99.24 Very High Very High Very High
Injury 18 97.20 Very High Very High Very High
Adhesions 18 95.32 Very High Very High Very High
Pre-eclampsia 72 93.08 High High
INFLAMMATION 48 92.08 High High
Cv General 3 Under Development 9 90.20 High High
Death 13 89.28 High High
Natriuresis 1 85.80 High High
Cv General 4 Under Development 9 84.44 Quite High
Adult Respiratory Distress Syndrome 42 82.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Negative_regulation (inhibitor) of tissue factor
1) Confidence 0.09 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.89 Pain Relevance 0.12
In mice deficient in tissue factor, the principal cellular activator of coagulation, APAP-induced liver injury, activation of coagulation, and hepatic fibrin deposition were reduced at 6 hours.
Negative_regulation (deficient) of tissue factor in liver associated with injury
2) Confidence 0.07 Published 2007 Journal Hepatology Section Abstract Doc Link 17654741 Disease Relevance 0.65 Pain Relevance 0.13
Knowing that pravastatin, by diminishing tissue factor levels, prevented miscarriages and growth restriction in the CBA/J x DBA/2 model [6], we sought to investigate whether pravastatin can prevent the onset of key features of PE in CBA/J x DBA/2 mice.
Negative_regulation (diminishing) of tissue factor associated with spontaneous abortion and pre-eclampsia
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.68 Pain Relevance 0
In addition, the treatment significantly reduced alveolar fibrin deposition, and decreased tissue factor and plasminogen activator inhibitor-1 activity in the serum.
Negative_regulation (decreased) of tissue factor
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2211395 Disease Relevance 1.16 Pain Relevance 0.17
Tissue factor reduction and tissue factor pathway inhibitor release after heparin administration.
Negative_regulation (reduction) of Tissue factor
5) Confidence 0.02 Published 1999 Journal Thromb. Haemost. Section Title Doc Link 10235445 Disease Relevance 0.34 Pain Relevance 0.38

General Comments

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