INT81776

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Context Info
Confidence 0.07
First Reported 1999
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.77
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
monocyte 2
macrophages 1
endothelial cells 1
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 99.22 Very High Very High Very High
agonist 11 97.48 Very High Very High Very High
Angina 6 94.76 High High
Inflammatory response 7 89.76 High High
Pain 9 88.24 High High
substance P 3 84.84 Quite High
Inflammation 53 82.68 Quite High
Glutamate 2 80.84 Quite High
Restless leg syndrome 3 74.32 Quite High
metalloproteinase 8 31.36 Quite Low
Disease Link Frequency Relevance Heat
Cancer 171 98.88 Very High Very High Very High
Atherosclerosis 12 97.32 Very High Very High Very High
Microphthalmia 23 95.64 Very High Very High Very High
Cv General 3 Under Development 6 94.76 High High
Injury 10 94.36 High High
Acute Coronary Syndrome 4 93.80 High High
Sarcoma 2 89.72 High High
INFLAMMATION 65 89.40 High High
Pain 6 88.24 High High
Apoptosis 15 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stx2 and EHEC-LPS induce tissue factor–positive microparticles
Positive_regulation (induce) of tissue factor
1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0 Pain Relevance 0.06
Study shows that F1 and F2 possess cardioprotective property with higher safety, while formulation F3 cannot be used as cardioprotective due to its cytotoxic effects.
Neg (cannot) Positive_regulation (formulation) of F3
2) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2952329 Disease Relevance 0 Pain Relevance 0.04
Along with serine proteases, it seems that tissue factor and element of the coagulation cascade are also endogenous activators of PARs [61,62].
Positive_regulation (activators) of tissue factor
3) Confidence 0.05 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.58 Pain Relevance 0.21
Elevated plasma levels of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) and large amounts of monocyte procoagulant activity (PCA) have been documented in unstable angina (UA) patients.
Positive_regulation (Elevated) of tissue factor in monocyte associated with angina
4) Confidence 0.02 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10235445 Disease Relevance 0.32 Pain Relevance 0.36
EMAP-II is a tumor-derived cytokine with potent effects on ECs, including induction of tissue factor, upregulation of TNF receptor 1, and upregulation of E-selectin and P-selectin [94].
Positive_regulation (induction) of tissue factor associated with cancer and cytokine
5) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.27 Pain Relevance 0.05
Increased levels of procoagulant plasma tissue factor (TF), arising from monocytes/macrophages and endothelial cells, is present in atherosclerosis.
Positive_regulation (Increased) of tissue factor in monocytes associated with atherosclerosis
6) Confidence 0.01 Published 2004 Journal Eur. Heart J. Section Abstract Doc Link 15033248 Disease Relevance 0.53 Pain Relevance 0.16
Increased levels of procoagulant plasma tissue factor (TF), arising from monocytes/macrophages and endothelial cells, is present in atherosclerosis.
Positive_regulation (Increased) of tissue factor in macrophages associated with atherosclerosis
7) Confidence 0.00 Published 2004 Journal Eur. Heart J. Section Abstract Doc Link 15033248 Disease Relevance 0.53 Pain Relevance 0.16
Increased levels of procoagulant plasma tissue factor (TF), arising from monocytes/macrophages and endothelial cells, is present in atherosclerosis.
Positive_regulation (Increased) of tissue factor in endothelial cells associated with atherosclerosis
8) Confidence 0.00 Published 2004 Journal Eur. Heart J. Section Abstract Doc Link 15033248 Disease Relevance 0.53 Pain Relevance 0.16

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