INT81777

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Context Info
Confidence 0.08
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 11.55
Pain Relevance 8.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
macrophages 5
liver 4
monocyte 3
naive T cells 2
neurons 2
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 844 100.00 Very High Very High Very High
Inflammation 398 100.00 Very High Very High Very High
metalloproteinase 211 100.00 Very High Very High Very High
antagonist 78 100.00 Very High Very High Very High
Spinal cord 3 99.88 Very High Very High Very High
COX-2 inhibitor 46 99.84 Very High Very High Very High
adenocard 5 99.14 Very High Very High Very High
cINOD 26 98.04 Very High Very High Very High
Angina 5 96.52 Very High Very High Very High
Leflunomide 15 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 425 100.00 Very High Very High Very High
Eosinophilia 39 100.00 Very High Very High Very High
Pneumonia 14 100.00 Very High Very High Very High
Injury 24 99.68 Very High Very High Very High
Shock 4 99.44 Very High Very High Very High
Hypersensitivity 36 99.28 Very High Very High Very High
Renal Disease 2 97.08 Very High Very High Very High
Toxicity 195 96.68 Very High Very High Very High
Cv General 3 Under Development 5 96.52 Very High Very High Very High
Asthma 639 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean (±SD) differences in preferred directions of all neurons tested during upright and RED in the CW and CCW directions were 4.7° ± 2.7° and ?
Negative_regulation (preferred) of Gene_expression (directions) of RED in neurons
1) Confidence 0.08 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Osteogenic differentiation and Alizarin Red S staining
Negative_regulation (differentiation) of Gene_expression (staining) of Red
2) Confidence 0.03 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.06 Pain Relevance 0.05
Adipogenic differentiation and Oil Red O staining
Negative_regulation (differentiation) of Gene_expression (staining) of Red
3) Confidence 0.03 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0 Pain Relevance 0.09
These results demonstrated that BCE has an anti-allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.
Negative_regulation (inhibition) of Gene_expression (expression) of cytokine gene in mast cells associated with hypersensitivity and cytokine
4) Confidence 0.02 Published 2004 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 15209365 Disease Relevance 0.64 Pain Relevance 0.15
Members of the MAP kinase family phosphorylate a number of transcription factors including runt-related transcription factor-2 (RUNX-2), with subsequent activation of matrix metalloproteinases (MMPs) and inflammatory cytokine gene expressions [3]. p38-MAPK, in particular, can regulate cytokine production through a variety of transcriptional and translational mechanisms [4].
Negative_regulation (number) of Gene_expression (expressions) of cytokine gene associated with inflammation, metalloproteinase and cytokine
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 1.02 Pain Relevance 0.74
Absence of proinflammatory cytokine gene expression in nasal biopsies from wood surface-coating industry workers.
Negative_regulation (Absence) of Gene_expression (expression) of cytokine in nasal associated with cytokine
6) Confidence 0.01 Published 2001 Journal Acta Otolaryngol. Section Title Doc Link 11678174 Disease Relevance 0.30 Pain Relevance 0.47
Typical scenarios are decreased leukocyte numbers affecting cytokine production, liver injury that impairs synthesis of binding proteins and clearance, renal dysfunction affecting clearance, and compromise of the intestinal barrier leading to endotoxin translocation and stimulation of inflammatory mediators.
Negative_regulation (numbers) of Gene_expression (production) of cytokine in liver associated with inflammatory mediators, renal disease, injury and cytokine
7) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 1.43 Pain Relevance 0.52
Typical scenarios are decreased leukocyte numbers affecting cytokine production, liver injury that impairs synthesis of binding proteins and clearance, renal dysfunction affecting clearance, and compromise of the intestinal barrier leading to endotoxin translocation and stimulation of inflammatory mediators.
Negative_regulation (decreased) of Gene_expression (production) of cytokine in liver associated with inflammatory mediators, renal disease, injury and cytokine
8) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 1.44 Pain Relevance 0.53
B signaling, reduces matrix metalloproteinase expression and inflammatory cytokine production [51], [59], [60], [61], [62].
Negative_regulation (reduces) of Gene_expression (production) of cytokine associated with inflammation, metalloproteinase and cytokine
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0.52 Pain Relevance 0.84
Overall, inhibition of cytokine gene expression by COX-2 inhibitor treatment and COX-2 knockdown were comparable.
Negative_regulation (inhibition) of Gene_expression (expression) of cytokine gene associated with cox-2 inhibitor and cytokine
10) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.61 Pain Relevance 0.40
S1P1Rs also mediate suppression of T cell proliferation and cytokine production.
Negative_regulation (suppression) of Gene_expression (production) of cytokine in T cell associated with cytokine
11) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.38
ligands also decrease antigen-induced airway hyperresponsiveness, lung inflammation and eosinophilia, cytokine production, and GATA-3 expression as well as serum levels of antigen-specific IgE in many different animal models of asthma [163,167-170].
Negative_regulation (decrease) of Gene_expression (production) of cytokine in lung associated with asthma, inflammation, pneumonia, eosinophilia and cytokine
12) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.79 Pain Relevance 0.34
Absence of 100% reduction in the expression of the examined cytokine genes by both methods could be due to the inability to inactivate or deplete COX-2 completely, paracrine effects of the released additional factors and/or additional factors besides COX-2 in the regulation of these genes in KSHV infected cells.
Negative_regulation (reduction) of Gene_expression (expression) of cytokine associated with herpes simplex virus and cytokine
13) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.57 Pain Relevance 0.48
In CaMKIV-deficient mice, whereas naive T cells did not express any apparent defect in cytokine expression, the expression of IL-2, IL-4, and IFN-?
Negative_regulation (defect) of Gene_expression (expression) of cytokine in naive T cells associated with cytokine
14) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.16
It was postulated that they may act via endorphin receptors, or by inhibiting prostaglandin synthesis.18 Other reports suggest that the marijuana derivative may act by inhibiting cytokine production and/or secretion.19,20 A recent clinical trial, however, has shown very little efficacy of either orally administered cannabinoid extract or ?
Negative_regulation (inhibiting) of Gene_expression (production) of cytokine associated with cannabinoid and cytokine
15) Confidence 0.00 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 1.06 Pain Relevance 0.32
The results showed: (1) CFA-induced peripheral inflammation evoked robust astrocyte activation and proinflammatory cytokines spinally; (2) down-regulation of cytokine mRNA transcripts by intrathecal administration of N/OFQ, the effects produced by N/OFQ were abolished by combination with ORL1 receptor-specific antagonist [Nphe(1)]N/OFQ(1-13)NH2; (3) ORL1 receptor was expressed on astrocytes of rat spinal cord; (4) cytokine gene expression was inhibited in astrocyte cultures exposed to N/OFQ, the inhibiting effects of N/OFQ were significantly blocked by [Nphe(1)]N/OFQ(1-13)NH2.
Negative_regulation (inhibited) of Gene_expression (expression) of cytokine gene in astrocytes associated with inflammation, antagonist, spinal cord, intrathecal and cytokine
16) Confidence 0.00 Published 2007 Journal Neuroscience Section Abstract Doc Link 17069983 Disease Relevance 0.68 Pain Relevance 0.97
Other novel agents include the interleukin (IL)-2 fusion toxin (ONTAK), pentostatin (a potent adenosine deaminase inhibitor), histone deacetylase inhibitors such as depsipeptide, NF-kappaB inhibitors, cytokine receptor antagonists, immunomodulatory therapies and allogeneic stem cell therapy.
Negative_regulation (inhibitors) of Gene_expression (antagonists) of cytokine in stem cell associated with adenocard, antagonist and cytokine
17) Confidence 0.00 Published 2003 Journal Leuk. Lymphoma Section Abstract Doc Link 15202526 Disease Relevance 0.95 Pain Relevance 0.28
CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs.


Negative_regulation (inhibit) of Gene_expression (production) of cytokine in placentas
18) Confidence 0.00 Published 2006 Journal J. Hypertens. Section Body Doc Link 16612254 Disease Relevance 0 Pain Relevance 0
In in vitro experiments heparin is able to blunt monocyte TF production by inhibiting TF and cytokine gene expression by stimulated cells and after in vivo administration it reduces adverse ischemic outcomes in UA patients.
Negative_regulation (inhibiting) of Gene_expression (expression) of cytokine gene in monocyte associated with angina and cytokine
19) Confidence 0.00 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10235445 Disease Relevance 0.37 Pain Relevance 0.42
Sodium salicylate (NaSal) and other nonsteroidal anti-inflammatory drugs (NSAIDs) coordinately inhibit the activity of NF-kappa B, activate heat shock transcription factor 1 and suppress cytokine gene expression in activated monocytes and macrophages.
Negative_regulation (suppress) of Gene_expression (expression) of cytokine gene in macrophages associated with inflammation, shock, cinod and cytokine
20) Confidence 0.00 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.20 Pain Relevance 0.48

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