INT81789

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.13

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cytosol (GIPC1) pigmentation (MC1R) protein targeting (GIPC1)
cytoplasmic membrane-bounded vesicle (GIPC1) plasma membrane (MC1R) cytoplasm (GIPC1)
MC1R (Homo sapiens)
GIPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 1 93.60 High High
antagonist 1 72.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Substitutions of the extracytoplasmic NH2 terminus and the first extracytoplasmic loop (exoloop) of the MC4R with homologous domains of the MC1R had no effect on AGRP (87-132) binding affinity or inhibitory activity (the ability to inhibit melanocortin-stimulated cAMP generation).
MC1R Binding (affinity) of terminus
1) Confidence 0.01 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.13

General Comments

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