INT81792

Context Info Confidence 0.01 First Reported 1999 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0 Pain Relevance 0.55

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)

AGRP (Homo sapiens) INSRR (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 4 99.80 antagonist 4 78.40

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.

AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor

1) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14

The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.

AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor

2) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14

The present studies were designed to examine the contribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making chimerical receptor constructs of the human melanocortin-1 receptor (MC1R; a receptor that is not inhibited by AGRP) and the human MC4R (a receptor that is potently inhibited by AGRP).

AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor

3) Confidence 0.01 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.14

The present studies were designed to examine the contribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making chimerical receptor constructs of the human melanocortin-1 receptor (MC1R; a receptor that is not inhibited by AGRP) and the human MC4R (a receptor that is potently inhibited by AGRP).

AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor

4) Confidence 0.01 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.14

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