INT81792

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Context Info
Confidence 0.01
First Reported 1999
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
AGRP (Homo sapiens)
INSRR (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 4 99.80 Very High Very High Very High
antagonist 4 78.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.
AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor
1) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14
The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.
AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor
2) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14
The present studies were designed to examine the contribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making chimerical receptor constructs of the human melanocortin-1 receptor (MC1R; a receptor that is not inhibited by AGRP) and the human MC4R (a receptor that is potently inhibited by AGRP).
AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor
3) Confidence 0.01 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.14
The present studies were designed to examine the contribution of extracytoplasmic domains of the melanocortin-4 receptor (MC4R) to AGRP binding by making chimerical receptor constructs of the human melanocortin-1 receptor (MC1R; a receptor that is not inhibited by AGRP) and the human MC4R (a receptor that is potently inhibited by AGRP).
AGRP Negative_regulation (inhibited) of receptor associated with melanocortin 1 receptor
4) Confidence 0.01 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.14

General Comments

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