INT81795

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 10.93
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
Anatomy Link Frequency
embryo 1
AGRP (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 7 91.08 High High
alcohol 155 90.08 High High
endometriosis 1 84.72 Quite High
Neuropeptide 3 81.88 Quite High
headache 27 79.76 Quite High
melanocortin 1 receptor 1 78.60 Quite High
cytokine 12 78.08 Quite High
methadone 6 77.16 Quite High
opiate 1 70.32 Quite High
tolerance 5 58.12 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1227 99.68 Very High Very High Very High
Reprotox - General 3 343 99.56 Very High Very High Very High
Opportunistic Infections 45 99.54 Very High Very High Very High
Infection 486 99.52 Very High Very High Very High
Cardiovascular Disease 1 98.84 Very High Very High Very High
Liver Failure 3 98.14 Very High Very High Very High
Disease Progression 67 97.96 Very High Very High Very High
Toxicity 74 97.92 Very High Very High Very High
Hepatitis B Virus Infection 3 97.60 Very High Very High Very High
Disease 119 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the number of specific infertility diagnoses increases for a couple, pregnancy and live birth rates from ART decrease.
Negative_regulation (decrease) of ART associated with reprotox - general 3
1) Confidence 0.41 Published 2006 Journal Matern Child Health J Section Body Doc Link PMC1592158 Disease Relevance 1.24 Pain Relevance 0.04
In contrast, cassette substitutions of exoloops 2 and 3 of the MC4R with the homologous exoloops of the MC1R resulted in a substantial loss of AGRP binding affinity and inhibitory activity.
Negative_regulation (loss) of AGRP
2) Confidence 0.41 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.11
This papers shows both that the major reasons why targets have not been reached, are that the current plans assume a constant availability of sufficient staff and that the loss of patients on ART has not been taken into account and that it is possible to estimate achievable targets if a limiting staff factor can be identified.
Negative_regulation (loss) of ART
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0 Pain Relevance 0
It assumes an annual loss of patients on ART of only 1%, equal to the age-specific mortality of the general population.
Negative_regulation (loss) of ART
4) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.09 Pain Relevance 0
iv) Financial burden of ART
Negative_regulation (burden) of ART
5) Confidence 0.37 Published 2006 Journal BMC Med Ethics Section Body Doc Link PMC1481581 Disease Relevance 0.11 Pain Relevance 0.05
More data are needed on the cost-effectiveness of starting ART earlier, including not only the costs associated with treating opportunistic infections but also the costs of delaying ART [30].
Negative_regulation (delaying) of ART associated with opportunistic infections
6) Confidence 0.32 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.10 Pain Relevance 0
A related health concern, which was the principal reason for delaying ART in developed countries, is the risk of accumulated drug toxicities.
Negative_regulation (delaying) of ART associated with toxicity
7) Confidence 0.32 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 1.07 Pain Relevance 0.08
We chose the Mann-Gostin Framework [4] because it is well suited to the analysis of policies that involve a restriction of rights, which can be considered to be the case when ART is deferred.
Negative_regulation (deferred) of ART
8) Confidence 0.32 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.06 Pain Relevance 0
More data are needed on the cost-effectiveness of starting ART earlier, including not only the costs associated with treating opportunistic infections but also the costs of delaying ART [30].
Negative_regulation (effectiveness) of ART associated with opportunistic infections
9) Confidence 0.32 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.10 Pain Relevance 0
His book was viewed with skepticism by many, as in this book review by John Milner published in the art journal Leonardo: “If the author points out a land where original marvels await discovery, then he may have achieved a great deal.
Negative_regulation (published) of art
10) Confidence 0.29 Published 2008 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736519 Disease Relevance 0.14 Pain Relevance 0
Nowadays, a policy of elective single embryo transfer (eSET) is reported as the most efficacious measure of reducing the incidence of multiple pregnancies in ART (Wolner-Hanssen and Rydhstroem, 1998; Gerris et al., 1999, 2004; Van Royen et al., 1999; Gerris, 2000; Tiitinen et al., 2001; De Sutter et al., 2002, 2003; Gerris and Van Royen, 2005).
Negative_regulation (reducing) of ART in embryo
11) Confidence 0.28 Published 2008 Journal Human Reproduction Update Section Body Doc Link PMC2569858 Disease Relevance 0.20 Pain Relevance 0
at least 80% of AIDS patients satisfying the treatment criteria should have received ART by 2010;mother-to-child transmission prevention services should be available in ?
Negative_regulation (received) of ART associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.27 Published 2010 Journal International Journal of Epidemiology Section Body Doc Link PMC2992621 Disease Relevance 0.62 Pain Relevance 0.15
Of the 246 pregnant women in ANC, 40 (16.3%) received combined ART, 164 (66.7%) PMTCT regimens, and 42 only PMTCT in labor, because of irregular or no ANC.
Negative_regulation (received) of ART
13) Confidence 0.25 Published 2009 Journal The Open AIDS Journal Section Body Doc Link PMC2695603 Disease Relevance 0.58 Pain Relevance 0
AGRP is an endogenous inhibitor of alpha-MSH, thereby promoting positive energy balance.
Negative_regulation (inhibitor) of AGRP
14) Confidence 0.23 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.16 Pain Relevance 0.09
In the past physicians working in developing countries mostly covered the cost of their training in ART and related procedures themselves, which also commonly included expenditure associated with living abroad for prolonged periods of time.
Negative_regulation (procedures) of ART
15) Confidence 0.20 Published 2008 Journal Human Reproduction Update Section Body Doc Link PMC2569858 Disease Relevance 0 Pain Relevance 0
and (3) What would be the expected implication on population growth if affordable infertility treatment, including ART, could be offered to infertile couples in developing countries?
Negative_regulation (offered) of ART associated with reprotox - general 3
16) Confidence 0.20 Published 2008 Journal Human Reproduction Update Section Body Doc Link PMC2569858 Disease Relevance 0.22 Pain Relevance 0
At the same time, antiretroviral therapy (ART) is thought to decrease some and restore other micronutrient levels [12, 13].
Negative_regulation (decrease) of ART
17) Confidence 0.14 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2938419 Disease Relevance 1.83 Pain Relevance 0.32
16 years failing their ART regimen, use of certain newer medications such as darunavir, maraviroc, or raltegravir may be considered.
Neg (failing) Negative_regulation (failing) of ART
18) Confidence 0.10 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 0.09 Pain Relevance 0
Also the risk of opportunistic diseases and non AIDS events like hepatic failure, renal and cardiovascular diseases with non AIDS malignancies were higher in patients whose ART was deferred till CD4 count dropped to <250 cells/ul than in those who commenced treatment with CD4 count >350 cells/ul.
Negative_regulation (deferred) of ART associated with liver failure, cardiovascular disease, acquired immune deficiency syndrome or hiv infection and disease
19) Confidence 0.09 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2918360 Disease Relevance 1.03 Pain Relevance 0.03
0.5 logs below set-point levels after discontinuation of ART and then decreased by ?
Negative_regulation (discontinuation) of ART
20) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.55 Pain Relevance 0

General Comments

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