INT81796

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Context Info
Confidence 0.36
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 62
Total Number 62
Disease Relevance 37.19
Pain Relevance 5.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
Anatomy Link Frequency
liver 2
T-cell 2
plasma 1
peritoneal fluid 1
superior 1
AGRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 65 99.92 Very High Very High Very High
alcohol 336 99.30 Very High Very High Very High
endometriosis 127 99.16 Very High Very High Very High
agonist 19 99.12 Very High Very High Very High
antagonist 32 98.88 Very High Very High Very High
Leflunomide 108 98.82 Very High Very High Very High
melanocortin 1 receptor 15 97.92 Very High Very High Very High
fibrosis 36 96.80 Very High Very High Very High
cytokine 89 96.18 Very High Very High Very High
tolerance 11 94.24 High High
Disease Link Frequency Relevance Heat
Stress 341 100.00 Very High Very High Very High
Skin Cancer 7 100.00 Very High Very High Very High
Thinness 2 100.00 Very High Very High Very High
Infection 558 99.98 Very High Very High Very High
Reprotox - General 3 191 99.84 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2568 99.60 Very High Very High Very High
Anaemia 81 99.58 Very High Very High Very High
Hepatotoxicity 30 99.54 Very High Very High Very High
Disease 380 99.36 Very High Very High Very High
Birth Weight 11 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contribution of melanocortin receptor exoloops to Agouti-related protein binding.
Agouti-related protein Binding (binding) of
1) Confidence 0.36 Published 1999 Journal J. Biol. Chem. Section Title Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.13
The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.
AGRP Binding (binding) of associated with melanocortin 1 receptor
2) Confidence 0.35 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14
Our previous studies have suggested that in addition to exoloops 2 and 3, several transmembrane domains of MC4R may be important for AGRP binding.
AGRP Binding (binding) of
3) Confidence 0.35 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12
These data indicate that exoloops 2 and 3 of the melanocortin receptors are important for AGRP binding.
AGRP Binding (binding) of
4) Confidence 0.35 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.06
Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are presently unknown.
AGRP Binding (binds) of
5) Confidence 0.35 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.12
In contrast, cassette substitutions of exoloops 2 and 3 of the MC4R with the homologous exoloops of the MC1R resulted in a substantial loss of AGRP binding affinity and inhibitory activity.
AGRP Binding (affinity) of
6) Confidence 0.35 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.11
According to government figures, in February 2006 some 61,981 people in Botswana were receiving ART, with 51,203 of them receiving treatment through the public sector and 2,460 out-sourced from the public sector [34].
ART Binding (receiving) of
7) Confidence 0.32 Published 2007 Journal BMC Int Health Hum Rights Section Body Doc Link PMC1903358 Disease Relevance 1.07 Pain Relevance 0
In one community where people had to travel for a day just to reach their nearest ART centre, a woman in her late 60 s explained to the team about her granddaughter's CD4 count and ART.
ART Binding (centre) of
8) Confidence 0.32 Published 2007 Journal BMC Int Health Hum Rights Section Body Doc Link PMC1903358 Disease Relevance 0.52 Pain Relevance 0
Reaching universal access will require increasing access to patients who currently are eligible for ART, but are either unable or unwilling to seek it.
ART Binding (eligible) of
9) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.21 Pain Relevance 0.08
Eligible subjects were those living within the catchment area of the ART clinic and were eligible for ART.
ART Binding (eligible) of
10) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.61 Pain Relevance 0.08
Our primary focus was on patients who were eligible for ART, but who chose not to initiate HIV treatment.
ART Binding (eligible) of associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.66 Pain Relevance 0.13
Some subjects in this group may not have been eligible for ART, and it is also possible that HBC caregivers mistook some illnesses for HIV/AIDS.
ART Binding (eligible) of associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.35 Pain Relevance 0
It is not clear what impact this would have had on our findings, but we note that there was little difference in our results when the analysis was limited to subjects who told us they had actively made the decision not to initiate ART.
ART Binding (initiate) of
13) Confidence 0.32 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.35 Pain Relevance 0
This supports previous findings that ART is associated with elevated risk of early parenting difficulties [31,32].
ART Binding (associated) of
14) Confidence 0.31 Published 2010 Journal Int J Ment Health Syst Section Body Doc Link PMC2873569 Disease Relevance 0.57 Pain Relevance 0.07
Additional work needs to be done to address the attendant issues of: low birth weight and possible increases in morbidity associated with ART, inequity in access to ART as well as access to preterm birth support as a consequence of ART, guidelines for the responsible use of ART; and attitudes and beliefs surrounding the value trade-offs that parents must make surrounding the use of ART, such as delayed reproduction and increased risk for preterm birth.
ART Binding (associated) of associated with birth weight and premature birth
15) Confidence 0.31 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841776 Disease Relevance 0.54 Pain Relevance 0
In contrast, cassette substitutions of the third or fourth transmembrane domain of the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 binding affinity and loss of AGRP 110-117 binding affinity.
AGRP Binding (affinity) of
16) Confidence 0.31 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.10
Our results indicate that substitutions of the second and third extracellular loops of the MC4R with homologous domains of the MC1R dramatically decreased AGRP 87-132 binding affinity, but did not affect AGRP 110-117 binding affinity.
AGRP Binding (affinity) of
17) Confidence 0.31 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12
In contrast, cassette substitutions of the third or fourth transmembrane domain of the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 binding affinity and loss of AGRP 110-117 binding affinity.
AGRP Binding (affinity) of
18) Confidence 0.31 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.11
The second and third extracellular loops of MC4R are important for AGRP 87-132 N-terminal binding, whereas the third and fourth transmembrane domains of hMC4R are crucial for AGRP 110-117 binding.
AGRP Binding (binding) of
19) Confidence 0.31 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.06
Our results indicate that substitutions of the second and third extracellular loops of the MC4R with homologous domains of the MC1R dramatically decreased AGRP 87-132 binding affinity, but did not affect AGRP 110-117 binding affinity.
AGRP Neg (not) Binding (affinity) of
20) Confidence 0.31 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12

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