INT81799

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.13
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
Anatomy Link Frequency
peritoneal fluid 2
AGRP (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 84 98.78 Very High Very High Very High
cytokine 40 96.68 Very High Very High Very High
melanocortin 1 receptor 4 89.12 High High
antagonist 4 67.20 Quite High
Dismenorea 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 218 100.00 Very High Very High Very High
Reprotox - General 3 84 99.34 Very High Very High Very High
Endometriosis (extended) 96 98.78 Very High Very High Very High
Intrauterine Growth Retardation 6 57.92 Quite High
Apoptosis 24 46.56 Quite Low
Increased Venous Pressure Under Development 8 35.20 Quite Low
Hypoxia 8 16.60 Low Low
Nicotine Addiction 12 5.72 Low Low
Eclampsia 40 5.00 Very Low Very Low Very Low
Pre-eclampsia 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, cassette substitutions of exoloops 2 and 3 of the MC4R with the homologous exoloops of the MC1R resulted in a substantial loss of AGRP binding affinity and inhibitory activity.
Negative_regulation (loss) of AGRP Binding (affinity) of
1) Confidence 0.42 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.11
Our results indicate that substitutions of the second and third extracellular loops of the MC4R with homologous domains of the MC1R dramatically decreased AGRP 87-132 binding affinity, but did not affect AGRP 110-117 binding affinity.
Negative_regulation (decreased) of AGRP Binding (affinity) of
2) Confidence 0.37 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.12
In contrast, cassette substitutions of the third or fourth transmembrane domain of the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 binding affinity and loss of AGRP 110-117 binding affinity.
Negative_regulation (loss) of AGRP Binding (affinity) of
3) Confidence 0.37 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.11
In contrast, cassette substitutions of the third or fourth transmembrane domain of the MC4R with the homologous domain of the MC1R resulted in a substantial decrease of AGRP 87-132 binding affinity and loss of AGRP 110-117 binding affinity.
Negative_regulation (decrease) of AGRP Binding (affinity) of
4) Confidence 0.37 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.11
cytokines and reactive oxygen species, which were increased in the peritoneal fluid of patients with endometriosis and unexplained infertility, were prevented, by the rinsing procedure.

3.6 Critical review of OS, ovary and ART

Negative_regulation (procedure.) of ART Binding (review) of in peritoneal fluid associated with stress, endometriosis, reprotox - general 3 and cytokine
5) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.62 Pain Relevance 0.14
3.1 Oxidative stress and its impact on ART
Negative_regulation (stress) of ART Binding (impact) of associated with stress
6) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.50 Pain Relevance 0.04

General Comments

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