INT81800

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
AGRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 60 99.92 Very High Very High Very High
Pain management 4 90.64 High High
Analgesic 11 80.96 Quite High
melanocortin 1 receptor 2 71.96 Quite High
antagonist 2 50.76 Quite High
qutenza 34 25.00 Low Low
cannabis 23 25.00 Low Low
Lamotrigine 18 25.00 Low Low
Endep 18 25.00 Low Low
Gabapentin 11 25.00 Low Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 84 99.60 Very High Very High Very High
Pain 52 90.64 High High
Neuropathy 8 89.32 High High
Neuropathic Pain 22 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Myalgia 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The second and third extracellular loops of MC4R are important for AGRP 87-132 N-terminal binding, whereas the third and fourth transmembrane domains of hMC4R are crucial for AGRP 110-117 binding.
Positive_regulation (important) of AGRP Binding (binding) of
1) Confidence 0.40 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.06
Conversely, the exchange of exoloops 2 and 3 of the MC1R with the homologous exoloops of the MC4R was found to confer AGRP binding and inhibitory activity to the basic structure of the MC1R.
Positive_regulation (confer) of AGRP Binding (binding) of
2) Confidence 0.39 Published 1999 Journal J. Biol. Chem. Section Abstract Doc Link 10318826 Disease Relevance 0 Pain Relevance 0.10
With the global HIV prevalence estimated at 33 million, and with infected individuals gaining increased access to ART, painful HIV-SN represents a large and expanding world health problem.
Positive_regulation (increased) of ART Binding (access) of associated with pain and acquired immune deficiency syndrome or hiv infection
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3010990 Disease Relevance 1.06 Pain Relevance 0.56

General Comments

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