INT81827

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.42
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnk2)
Kcnk2 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 48 100.00 Very High Very High Very High
halothane 45 100.00 Very High Very High Very High
anesthesia 5 98.84 Very High Very High Very High
nociceptor 16 94.04 High High
analgesia 9 91.68 High High
Peripheral nervous system 1 79.12 Quite High
potassium channel 25 77.32 Quite High
sodium channel 2 73.92 Quite High
Nav1.7 3 72.72 Quite High
Pyramidal cell 12 60.08 Quite High
Disease Link Frequency Relevance Heat
Amnesia 6 91.12 High High
Unconsciousness 10 90.76 High High
Erythermalgia 1 70.40 Quite High
Targeted Disruption 19 48.56 Quite Low
Depression 104 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 48 5.00 Very Low Very Low Very Low
Anxiety Disorder 39 5.00 Very Low Very Low Very Low
Stress 22 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Shock 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As previously described [21], TREK-1 basal channel activity was strongly and reversibly activated by arachidonic acid (aa, 10 µM), which induced a typical TREK-1 background current, characterized by outward rectification reversed at the predicted value for EK+.
Positive_regulation (activated) of TREK-1
1) Confidence 0.70 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0
4) of the aa stimulated TREK-1 current measured at 0 mV (Figure 3A).
Positive_regulation (stimulated) of TREK-1
2) Confidence 0.50 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0.03
As previously described [21], TREK-1 basal channel activity was strongly and reversibly activated by arachidonic acid (aa, 10 µM), which induced a typical TREK-1 background current, characterized by outward rectification reversed at the predicted value for EK+.
Positive_regulation (induced) of TREK-1
3) Confidence 0.47 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0 Pain Relevance 0
Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK.
Positive_regulation (activated) of TREK-1 associated with isoflurane and halothane
4) Confidence 0.16 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10321245 Disease Relevance 0.17 Pain Relevance 0.37
Here we show that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics.
Positive_regulation (activated) of TREK-1
5) Confidence 0.16 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10321245 Disease Relevance 0.18 Pain Relevance 0.38
The activity of both channels is augmented by heat [89,16] but, while activation of TREK-1 acts as a brake, TRPV1 drives the excitation.
Positive_regulation (activation) of TREK-1
6) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.07 Pain Relevance 0.36
Patel et al. (1999) examined TASK and TREK-1, and found that TREK-1 was activated by chloroform, diethyl ether, halothane and isoflurane, while TASK was activated by halothane and isoflurane.
Positive_regulation (activated) of TREK-1 associated with isoflurane and halothane
7) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.33
Patel et al. (1999) examined TASK and TREK-1, and found that TREK-1 was activated by chloroform, diethyl ether, halothane and isoflurane, while TASK was activated by halothane and isoflurane.
Positive_regulation (activated) of TREK-1 associated with isoflurane and halothane
8) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.32

General Comments

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