INT81828

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.43
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnk3) plasma membrane (Kcnk3)
Anatomy Link Frequency
pore 1
Kcnk3 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 25 99.98 Very High Very High Very High
halothane 26 99.84 Very High Very High Very High
anesthesia 2 99.20 Very High Very High Very High
noradrenaline 1 99.06 Very High Very High Very High
Eae 1 98.84 Very High Very High Very High
agonist 14 92.20 High High
analgesia 5 92.04 High High
Cannabinoid 4 91.84 High High
potassium channel 3 74.00 Quite High
ketamine 1 51.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 26 100.00 Very High Very High Very High
Amnesia 4 91.48 High High
Unconsciousness 6 91.12 High High
Cognitive Disorder 4 75.00 Quite High
Post-traumatic Stress Disorder 1 57.12 Quite High
Nociception 1 50.32 Quite High
Pain 30 30.64 Quite Low
Fatigue 5 29.20 Quite Low
Neck Pain 19 5.00 Very Low Very Low Very Low
Phobia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circadian locomotor activity measurements revealed that the nocturnal activity of the TASK-3 KO mice was increased by 38% (P < 0.01) compared with wild-type littermate controls, light phase activity being similar.
Positive_regulation (increased) of TASK-3 KO associated with targeted disruption and eae
1) Confidence 0.45 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17875609 Disease Relevance 0.71 Pain Relevance 0.05
Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated TASK.
Positive_regulation (activated) of TASK associated with isoflurane and halothane
2) Confidence 0.43 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10321245 Disease Relevance 0.16 Pain Relevance 0.37
Here we show that TASK and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics.
Positive_regulation (activated) of TASK
3) Confidence 0.43 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10321245 Disease Relevance 0.18 Pain Relevance 0.38
Many neuromodulators, such as noradrenaline, might also manifest some of their actions by modifying TASK channel activity.
Positive_regulation (modifying) of TASK associated with noradrenaline
4) Confidence 0.41 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16397088 Disease Relevance 0.38 Pain Relevance 0.42
Patel et al. (1999) examined TASK and TREK-1, and found that TREK-1 was activated by chloroform, diethyl ether, halothane and isoflurane, while TASK was activated by halothane and isoflurane.
Positive_regulation (activated) of TASK associated with isoflurane and halothane
5) Confidence 0.06 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989583 Disease Relevance 0 Pain Relevance 0.33
RESULTS: Both drugs inhibit cTBAK-1 current: FL proved to be a voltage-dependent pore-blocker, while NORP induced a change in the selectivity of cTBAK-1 giving rise to a shift in the reversal potential (E(rev)) toward more positive voltages due to an increased Na(+) permeability.
Positive_regulation (induced) of cTBAK-1 in pore
6) Confidence 0.04 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12667945 Disease Relevance 0 Pain Relevance 0
When the subject had acquired the skill to complete at least five trials in a block of six trials, with each trial completed within 30 s, the difficulty of the task was increased by changing the surface to a faster one (i.e., lower rolling resistance).
Positive_regulation (increased) of task
7) Confidence 0.04 Published 2008 Journal J Neuroeng Rehabil Section Body Doc Link PMC2625342 Disease Relevance 0 Pain Relevance 0

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