INT81830

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Context Info
Confidence 0.73
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 5.42
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
nerve 3
gut 1
hypothalamus 1
neurons 1
sensory nerve 1
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
Pain 31 99.92 Very High Very High Very High
dorsal root ganglion 43 99.68 Very High Very High Very High
adenocard 69 98.20 Very High Very High Very High
Dorsal horn 10 96.68 Very High Very High Very High
Central nervous system 11 96.08 Very High Very High Very High
qutenza 84 95.80 Very High Very High Very High
Neuropathic pain 6 95.76 Very High Very High Very High
wide dynamic range 1 90.28 High High
Inflammation 54 86.80 High High
Disease Link Frequency Relevance Heat
Pain 32 99.92 Very High Very High Very High
Nervous System Injury 4 99.28 Very High Very High Very High
Ganglion Cysts 44 99.20 Very High Very High Very High
Nociception 63 99.16 Very High Very High Very High
Asthma 11 97.48 Very High Very High Very High
Targeted Disruption 7 96.84 Very High Very High Very High
Colitis 3 96.60 Very High Very High Very High
Neuropathic Pain 9 95.76 Very High Very High Very High
Hypoxia 122 90.96 High High
Body Weight 1 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds.
Localization (Localization) of P2X2 in taste buds
1) Confidence 0.73 Published 1999 Journal Neuroreport Section Title Doc Link 10321492 Disease Relevance 0.09 Pain Relevance 0.13
ATP released during distension from epithelial cells lining tubes (such as ureter or gut), and sacs (such as bladder), acts on P2X3 and/or P2X2/3 receptors on a subepithelial sensory nerve plexus to initiate impulses that are relayed to the central nervous system via extrinsic spinal afferents such as the pelvic nerve.
Localization (released) of P2X2 in gut associated with central nervous system
2) Confidence 0.61 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2104004 Disease Relevance 0 Pain Relevance 0.09
Furthermore, P2X receptors are also localized to the afferent nerve endings apposed to the glomus cluster [31].
Localization (localized) of P2X in glomus
3) Confidence 0.59 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.43 Pain Relevance 0
In this context, Campanucci et al. [39] recently reported that P2X receptors are localized to the efferent nerve endings and activation of these receptors by ATP could lead to an inhibition of chemoreceptor activities via an NO mechanism.
Localization (localized) of P2X in nerve
4) Confidence 0.59 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.43 Pain Relevance 0
These effects of MTSEA and MTSES are broadly consistent for both the P2X2 and P2X4 receptors.
Localization (receptors) of P2X2
5) Confidence 0.44 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2459275 Disease Relevance 0 Pain Relevance 0.03
After nerve injury, the mRNA of P2X(5) was increased, those of P2X(3) and P2X(6) were decreased, and those of P2X(2) and P2X(4) were unchanged.
Localization (those) of P2X in nerve associated with nervous system injury
6) Confidence 0.35 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12527393 Disease Relevance 0.33 Pain Relevance 0.27
After nerve injury, the mRNA of P2X(5) was increased, those of P2X(3) and P2X(6) were decreased, and those of P2X(2) and P2X(4) were unchanged.
Localization (those) of P2X in nerve associated with nervous system injury
7) Confidence 0.35 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12527393 Disease Relevance 0.33 Pain Relevance 0.27
ATP release and P2X3 and P2X2/3 receptor-mediated nociceptive sensory nerve responses were enhanced in a model of colitis consisting of administration to adult rats of an intrarectal enema of 30% trinitro benzene sulfonic acid in ethanol at a dose of 80 mg/kg body weight [67].
Localization (release) of P2X2 in sensory nerve associated with colitis, nociception and body weight
8) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2789721 Disease Relevance 0.83 Pain Relevance 0.33
PIP2 rescues P2X3 and P2X2 current responses from rundown in excised inside-out macropatches
Localization (responses) of P2X2
9) Confidence 0.21 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0 Pain Relevance 0
There is also evidence from the study involving our laboratory of a widespread co-localization of neuronal NO synthase and P2X receptors in the hypothalamus (Yao et al. 2003).
Localization (localization) of P2X in hypothalamus
10) Confidence 0.14 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375460 Disease Relevance 0.33 Pain Relevance 0.10
The synaptic modulation is mediated by the activation of P2X receptors and these P2X receptors are localized at the presynaptic terminals of afferent fibers innervating lamina V neurons.
Localization (localized) of P2X in lamina
11) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074354 Disease Relevance 0.72 Pain Relevance 0.61
Taken together these data suggest that while A(1) receptors might became desensitized, A(2A) and P2X receptor-mediated facilitation of glutamate release by endogenous ATP and its breakdown product adenosine remains operational under long-term OGD.
Localization (release) of P2X associated with adenocard and glutamate
12) Confidence 0.06 Published 2007 Journal Neuroscience Section Abstract Doc Link 17850981 Disease Relevance 0.06 Pain Relevance 0.63
P2X(3) receptors are localized in the dorsal root ganglion (DRG) neurons and activated by extracellular ATP.
Localization (localized) of P2X in neurons associated with ganglion cysts and dorsal root ganglion
13) Confidence 0.05 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18805451 Disease Relevance 1.11 Pain Relevance 0.61
Since ROS may promote the release of ATP from cells, we hypothesized that activation of P2X purinoceptors by ATP subsequent to an increase in ROS induces LAH in an inflamed larynx that has been insulted by acid-pepsin or H(2)O(2) (a major type of ROS).
Localization (release) of P2X in larynx associated with asthma
14) Confidence 0.04 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19246655 Disease Relevance 0.63 Pain Relevance 0.10

General Comments

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