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Context Info
Confidence 0.07
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
ADRA2C (Homo sapiens)
CRYGS (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
antagonist 1 95.36 Very High Very High Very High
Clonidine 1 45.68 Quite Low


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under optimal conditions, the potent alpha2-AR agonist, 5-bromo-6-(2-imidazolin-2-ylamino)-quinoxaline (UK 14304), increased the binding of [35S]GTPgammaS up to approximately 1.8 fold, with half-maximal increase at 60 nM and was competitively inhibited by the alpha2-AR antagonist Rauwolscine.
Positive_regulation (increased) of alpha2-AR Binding (binding) of GTPgammaS associated with antagonist and agonist
1) Confidence 0.07 Published 1999 Journal Life Sci. Section Abstract Doc Link 10321720 Disease Relevance 0 Pain Relevance 0.14

General Comments

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