INT81870

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) aging (Aldh3a1)
endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 5 97.98 Very High Very High Very High
cINOD 3 81.68 Quite High
addiction 10 69.12 Quite High
tolerance 28 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 97.98 Very High Very High Very High
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect is reduced by commonly used steroid and non-steroid anti- inflammatory drugs, and although the mechanism of inhibition has not yet been elucidated, it appears likely that ALDH3c and CYP1A activities are associated with the "acute phase" response.
ALDH3c Spec (likely) Binding (associated) of associated with inflammation
1) Confidence 0.27 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.47 Pain Relevance 0.42
Inactivation and Reactivation of ALDH2-catalyzed GTN
Reduction—To assess how GTN affects its own reduction by
mitochondrial ALDH we measured GTN reductase activity, removed low molecular
weight ingredients from the assay mixture by gel filtration, and repeated the
activity assay with the recovered enzyme. 
mitochondrial ALDH Binding (reduction) of
2) Confidence 0.15 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
This was ascribed to the
absence of NAD+, which has been reported to increase the substrate
affinity of mitochondrial ALDH
(20). 
mitochondrial ALDH Binding (affinity) of
3) Confidence 0.14 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.03

General Comments

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