INT81871

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 3.15
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) aging (Aldh3a1)
endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Anatomy Link Frequency
hepatocyte 3
hematopoietic stem cells 1
liver 1
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 32 99.82 Very High Very High Very High
Inflammation 53 98.48 Very High Very High Very High
Dopamine 20 93.40 High High
tolerance 34 84.64 Quite High
agonist 2 76.56 Quite High
Nicotine 1 75.12 Quite High
tetrodotoxin 1 71.04 Quite High
addiction 10 70.08 Quite High
sodium channel 1 67.44 Quite High
Calcium channel 1 65.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 76 99.54 Very High Very High Very High
Stress 82 97.00 Very High Very High Very High
Targeted Disruption 7 81.44 Quite High
Disease 31 51.12 Quite High
Apoptosis 12 11.32 Low Low
Inflammatory Breast Neoplasms 34 5.00 Very Low Very Low Very Low
Premature Birth 19 5.00 Very Low Very Low Very Low
Death 18 5.00 Very Low Very Low Very Low
Sepsis 17 5.00 Very Low Very Low Very Low
Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.
Positive_regulation (increased) of ALDH3A1
1) Confidence 0.69 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0 Pain Relevance 0
Acute-phase response to benzo[a]pyrene and induction of rat ALDH3A1.
Positive_regulation (induction) of ALDH3A1
2) Confidence 0.69 Published 2003 Journal Chem. Biol. Interact. Section Title Doc Link 12604189 Disease Relevance 0 Pain Relevance 0
Considering the changes of APPs caused by BaP, this study further supports the suggestion that the induction of ALDH3A1 is related to an atypical hepatocyte inflammation produced by xenobiotics.
Positive_regulation (induction) of ALDH3A1 in hepatocyte associated with inflammation
3) Confidence 0.69 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0.19 Pain Relevance 0.23
Former studies of our group have shown that the inhibitory effects of different non-steroidal anti-inflammatory drugs (NSAIDs) on the ALDH3A1 induction were most possibly due to a decreased formation of arachidonic products like prostaglandins.
Positive_regulation (induction) of ALDH3A1 associated with inflammation and cinod
4) Confidence 0.69 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0.10 Pain Relevance 0.24
Although much is known regarding the mechanism for the drug-metabolizing enzymes up-regulated by the Ah receptor, the physiological role of that tremendously increased ALDH3A1 enzyme activity is not yet fully clarified.
Positive_regulation (increased) of ALDH3A1
5) Confidence 0.69 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0 Pain Relevance 0
The aldehyde dehydrogenase-3A1 (ALDH3A1) enzyme, encoded by a member of the [Ah]-gene family, is dramatically increased (more than 100-fold) by benzo[a]pyrene (BaP) and other polycyclic hydrocarbons.
Positive_regulation (increased) of dehydrogenase-3A1
6) Confidence 0.60 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0 Pain Relevance 0
NSCs, like hematopoietic stem cells, express high levels of aldehyde dehydrogenase (ALDH) as assessed by Aldefluor labeling.
Positive_regulation (levels) of ALDH in hematopoietic stem cells
7) Confidence 0.53 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675165 Disease Relevance 0 Pain Relevance 0.24
In the present study we investigated whether the induction of ALDH3c might be connected with a chemically produced aseptic inflammation of the hepatocyte.
Positive_regulation (induction) of ALDH3c in hepatocyte associated with inflammation
8) Confidence 0.53 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.32 Pain Relevance 0.33
The 3MC-induced ALDH3c activity was significantly diminished by the co-administered anti-inflammatory agents.
Positive_regulation (induced) of ALDH3c associated with inflammation
9) Confidence 0.53 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.47 Pain Relevance 0.46
In conclusion, the induction of ALDH3c, after PAH treatment, may be related to an aseptic inflammation of the hepatocytes.
Positive_regulation (induction) of ALDH3c in hepatocytes associated with inflammation
10) Confidence 0.53 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.50 Pain Relevance 0.46
Additionally, ALDH3A1, CRP, and HPT were induced by BaP subacute treatment, whereas another type of ALDH inducer, phenobarbital, did not affect the levels of APPs or ALDH3A1, but did increase ALDH1A3 activity.
Positive_regulation (induced) of ALDH3A1
11) Confidence 0.50 Published 2003 Journal Chem. Biol. Interact. Section Abstract Doc Link 12604189 Disease Relevance 0.08 Pain Relevance 0.18
To answer this question, we examined the relationship between the induction of ALDH3c by 3MC and the arachidonic acid cascade.
Spec (examined) Positive_regulation (induction) of ALDH3c
12) Confidence 0.38 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.35 Pain Relevance 0.38
ALDHI is mainly increased by phenobarbital-type inducers; polycyclic aromatic hydrocarbons (PAHs), such as 3- methylcholanthrene (3MC), increase ALDH3c enzyme activity in all rat species currently tested.
Positive_regulation (increase) of ALDH3c
13) Confidence 0.35 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.19 Pain Relevance 0.12
Two rat liver cytosolic aldehyde dehydrogenases, ALDH1 and ALDH3c, are of particular interest because they are inducible by different classes of xenobiotics.
Positive_regulation (inducible) of ALDH3c in liver
14) Confidence 0.35 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.13 Pain Relevance 0.06
Activities of ALDH2 after GTN Preconditioning—In the
experiments described so far, we studied the inactivation of ALDH in real time
by monitoring the dehydrogenase and esterase activities in the presence of
GTN. 
Positive_regulation (inactivation) of ALDH
15) Confidence 0.23 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
This was ascribed to the
absence of NAD+, which has been reported to increase the substrate
affinity of mitochondrial ALDH
(20). 
Positive_regulation (increase) of mitochondrial ALDH
16) Confidence 0.20 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.04
Reductases can compensate for impaired ALDH activity, and indeed, treatment of dopaminergic PC6-3 cells with 4HNE yielded both an increase in (DOPAL) but also (DOPET), compared with control.
Positive_regulation (compensate) of ALDH
17) Confidence 0.06 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.22 Pain Relevance 0.30
In C. plantagineum, a resurrection plant that can withstand almost 100% water loss for several years, the activity of CpALDH (ALDH3) was elevated during extreme desiccation to allow the plant to survive in environmental stress conditions in which other plants cannot survive [15].
Positive_regulation (elevated) of CpALDH associated with stress
18) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.61 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox