INT8188

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 7.32
Pain Relevance 10.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb3) plasma membrane (Adrb3) nucleus (Adrb3)
signal transducer activity (Adrb3)
Anatomy Link Frequency
smooth muscle 2
spike 2
nucleus 2
sympathetic 2
visceral 1
Adrb3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 28 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
noradrenaline 6 99.98 Very High Very High Very High
Morphine 27 99.84 Very High Very High Very High
tetrodotoxin 6 99.84 Very High Very High Very High
withdrawal 33 99.52 Very High Very High Very High
opiate 3 99.36 Very High Very High Very High
cva 3 98.52 Very High Very High Very High
Neurotransmitter 1 98.08 Very High Very High Very High
Opioid 5 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 1 100.00 Very High Very High Very High
Overactive Bladder 3 99.92 Very High Very High Very High
Coronary Artery Disease 8 99.90 Very High Very High Very High
Atherosclerosis 12 99.84 Very High Very High Very High
Obesity 14 99.40 Very High Very High Very High
Cv General 3 Under Development 3 98.52 Very High Very High Very High
Stress 5 98.24 Very High Very High Very High
Anxiety Disorder 5 97.16 Very High Very High Very High
Hypotension 6 96.52 Very High Very High Very High
Pain 6 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirm previous evidence against the involvement of beta-adrenoceptor upregulation on morphine withdrawal behaviors and also permit to discard beta-adrenoceptor regulation as the neurochemical basis of the antiwithdrawal effect of yohimbine.
Positive_regulation (upregulation) of beta-adrenoceptor associated with withdrawal and morphine
1) Confidence 0.68 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077587 Disease Relevance 0.13 Pain Relevance 1.26
Morphine-treated animals displayed a marked withdrawal behavior together with beta-adrenoceptor upregulation; nevertheless, these effects were not correlated.
Positive_regulation (upregulation) of beta-adrenoceptor associated with withdrawal and morphine
2) Confidence 0.68 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077587 Disease Relevance 0.14 Pain Relevance 1.28
Thus, activation of the renin-angiotensin system, fluid retention and beta-adrenoceptor subsensitivity seemed to be ruled out from the mechanism of this acute tolerance to pindolol.
Positive_regulation (activation) of beta-adrenoceptor associated with pressure and volume under development and tolerance
3) Confidence 0.62 Published 1983 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6141128 Disease Relevance 0.67 Pain Relevance 0.29
Furthermore, it indicates that the nerves responsible for the propagation of the inhibitory effect to beta-adrenoceptor stimulation in the nervous plexa are not of the cholinergic type.
Positive_regulation (stimulation) of beta-adrenoceptor in nerves
4) Confidence 0.49 Published 1985 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2869641 Disease Relevance 0 Pain Relevance 0.22
Noradrenaline caused a beta-adrenoceptor mediated relaxation of the smooth muscle bands. 4.
Positive_regulation (caused) of beta-adrenoceptor in smooth muscle associated with noradrenaline
5) Confidence 0.47 Published 1987 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 2443303 Disease Relevance 0 Pain Relevance 0.19
Although other factors may be involved, adaptive up-regulation of beta-adrenoceptor density is the most likely cause of crescendo angina, and renders the patient more susceptible to sympathetic nervous stimulation following withdrawal of treatment.
Positive_regulation (up-regulation) of beta-adrenoceptor in sympathetic associated with cva and withdrawal
6) Confidence 0.47 Published 1987 Journal Med Toxicol Adverse Drug Exp Section Abstract Doc Link 3312931 Disease Relevance 0.69 Pain Relevance 0.69
In summary, these results are consistent with the hypothesis that idazoxan potentiates granule cell responses to perforant path input in the dentate gyrus via increases in norepinephrine that lead to beta-adrenoceptor activation, and, further, that idazoxan reduces paired pulse feedback spike facilitation and enhances EPSP slope, but not spike, feedback inhibition.
Positive_regulation (activation) of beta-adrenoceptor in spike
7) Confidence 0.47 Published 2006 Journal Brain Res. Section Abstract Doc Link 16426582 Disease Relevance 0 Pain Relevance 0.04
All patients were receiving beta-adrenoceptor blocking therapy.
Positive_regulation (receiving) of beta-adrenoceptor
8) Confidence 0.46 Published 1988 Journal Br J Anaesth Section Abstract Doc Link 2967711 Disease Relevance 0.07 Pain Relevance 0.09
These results suggest that the anxiolytic- and antidepressant-like activities of SR58611A involve an increase of brain serotonergic and noradrenergic neurotransmissions, triggered by activation of Adrb3s.
Positive_regulation (activation) of Adrb3s in brain associated with antidepressant and anxiety disorder
9) Confidence 0.46 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.32 Pain Relevance 0.26
As expected, yohimbine prevented morphine withdrawal behavior but did not reverse the beta-adrenoceptor upregulation induced by the opiate.
Positive_regulation (upregulation) of beta-adrenoceptor associated with opiate, withdrawal and morphine
10) Confidence 0.45 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077587 Disease Relevance 0.14 Pain Relevance 1.28
This hypothesis was confirmed by the reduced maximal inhibitory response of the partial beta-adrenoceptor agonist, prenalterol, induced by tetrodotoxin.
Positive_regulation (induced) of partial beta-adrenoceptor associated with tetrodotoxin and agonist
11) Confidence 0.45 Published 1985 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2869641 Disease Relevance 0 Pain Relevance 0.49
beta-Adrenoceptor stimulation-induced increase in the number of alpha 2-adrenoceptors of cerebral cortical membranes in rats.
Positive_regulation (increase) of beta-Adrenoceptor
12) Confidence 0.44 Published 1985 Journal Brain Res. Section Title Doc Link 2983840 Disease Relevance 0.16 Pain Relevance 0.46
The results demonstrated that stimulation of alpha- and beta-adrenoceptor in the paraventricular nucleus induced potent antidiuretic effects, partial inhibition of which by atropine suggested a possible presynaptic facilitation of the release of ACh by the stimulation of the adrenoceptors.
Positive_regulation (stimulation) of beta-adrenoceptor in nucleus
13) Confidence 0.43 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2871211 Disease Relevance 0 Pain Relevance 0.22
A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity.
Positive_regulation (increase) of beta-adrenoreceptor
14) Confidence 0.43 Published 1991 Journal Cor Vasa Section Abstract Doc Link 1655353 Disease Relevance 0.53 Pain Relevance 0.14
Here, the reduction in spike potentiation on the timolol pipette is consistent with other evidence that norepinephrine-mediated potentiation of the perforant path-evoked potential is dependent on local beta-adrenoceptor activation.
Positive_regulation (activation) of beta-adrenoceptor in spike
15) Confidence 0.41 Published 2006 Journal Brain Res. Section Abstract Doc Link 16426582 Disease Relevance 0 Pain Relevance 0.09
During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations.
Positive_regulation (activated) of beta-adrenoceptor associated with coronary artery disease
16) Confidence 0.34 Published 1999 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10525419 Disease Relevance 0.18 Pain Relevance 0.19
In view of the postulated roles of platelets and beta-adrenoceptor activation in atherosclerosis development, we decided to test whether beta blockade affects arterial platelet accumulation.
Positive_regulation (activation) of beta-adrenoceptor in platelet associated with atherosclerosis
17) Confidence 0.30 Published 1992 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 1450095 Disease Relevance 0.64 Pain Relevance 0.12
Psychosocial stress has been shown to accelerate atherogenesis in animals, an effect probably mediated via beta-adrenoceptor activation.
Positive_regulation (activation) of beta-adrenoceptor associated with stress and atherosclerosis
18) Confidence 0.30 Published 1992 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 1450095 Disease Relevance 0.66 Pain Relevance 0.06
This is a reproducible model of experimental sympathetic activation, including beta-adrenoceptor activation, which we used to amplify possible effects of beta-blockade on platelet-vessel wall interaction.
Positive_regulation (activation) of beta-adrenoceptor in sympathetic
19) Confidence 0.30 Published 1992 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 1450095 Disease Relevance 0.51 Pain Relevance 0.19
Activation of the beta-adrenoceptor-protein kinase A signaling pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain in rats.
Positive_regulation (Activation) of beta-adrenoceptor in nucleus associated with pain
20) Confidence 0.22 Published 2008 Journal J. Neurosci. Section Title Doc Link 18667605 Disease Relevance 0.66 Pain Relevance 0.67

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