INT81880

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 27.54
Pain Relevance 7.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sele) cell adhesion (Sele)
Anatomy Link Frequency
endothelial cells 10
joints 8
leukocyte 6
extracellular matrix 4
lung 4
Sele (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 798 100.00 Very High Very High Very High
cytokine 468 100.00 Very High Very High Very High
Inflammatory mediators 49 100.00 Very High Very High Very High
Arthritis 681 99.66 Very High Very High Very High
licofelone 8 99.66 Very High Very High Very High
antagonist 99 99.52 Very High Very High Very High
cINOD 24 99.48 Very High Very High Very High
rheumatoid arthritis 79 97.68 Very High Very High Very High
COX-2 inhibitor 5 97.20 Very High Very High Very High
Inflammatory response 117 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 914 100.00 Very High Very High Very High
Adhesions 388 100.00 Very High Very High Very High
Necrosis 60 100.00 Very High Very High Very High
Atherosclerosis 58 100.00 Very High Very High Very High
Cancer 57 100.00 Very High Very High Very High
Arthritis 770 99.82 Very High Very High Very High
Disorder Of Lipid Metabolism 274 99.32 Very High Very High Very High
Stroke 176 99.22 Very High Very High Very High
Asthma 87 98.98 Very High Very High Very High
Hypothermia 202 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-selectin is expressed on the majority of leukocytes and is shed from the cell surface following activation, whereas P-selectin and E-selectin are expressed on endothelial cells following activation by various inflammatory mediators.
Positive_regulation (activation) of Gene_expression (expressed) of E-selectin in leukocytes associated with inflammatory mediators
1) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.51 Pain Relevance 0.11
Increased expression of E-selectin and P-selectin has been observed in inflamed joints from RA patients, with several studies showing significant elevations in soluble selectins in the serum of patients with active disease [7-10].
Positive_regulation (Increased) of Gene_expression (expression) of E-selectin in joints associated with rheumatoid arthritis and disease
2) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.19 Pain Relevance 0.46
Our previous and current studies in the CIA model show that leukocyte rolling via E-selectin and P-selectin is not required for the initiation of arthritis, and that loss of one or both of these adhesion molecules significantly accelerates the development and severity of joint inflammation.
Neg (not) Positive_regulation (required) of Gene_expression (leukocyte) of E-selectin in joint associated with inflammation, adhesions and arthritis
3) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.28 Pain Relevance 0.55
These findings indicate that in early-onset arthritic joints, expression of E-selectin and P-selectin can significantly influence the production of IL-1?
Positive_regulation (influence) of Gene_expression (expression) of E-selectin in joints associated with arthritis
4) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.84 Pain Relevance 0.31
Therefore, the increased cytokine production in the E/P-selectin mutant mice cannot be fully explained by elevated white blood cell numbers.
Positive_regulation (increased) of Gene_expression (production) of E/P-selectin in white blood cell associated with cytokine
5) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.56 Pain Relevance 0.29
Serum and joint IL-1 receptor antagonist protein levels are not elevated in E/P-selectin mutant compared with wild-type mice
Neg (not) Positive_regulation (elevated) of Neg (not) Gene_expression (mutant) of E/P-selectin in joint associated with antagonist
6) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 0.41 Pain Relevance 0.21
C-UA, but not T-UA, induced local effects of liberated mast cell TNF-alpha, as detected by E-selectin expression on the microvascular dermal endothelium.
Positive_regulation (detected) of Gene_expression (expression) of E-selectin in endothelium
7) Confidence 0.41 Published 1999 Journal Skin Pharmacol. Appl. Skin Physiol. Section Abstract Doc Link 10325580 Disease Relevance 0.43 Pain Relevance 0.15
In the presence of licofelone (30 microM) the expression of E-selectin mRNA in cytokine-stimulated EC was attenuated, whereas no NSAID (30 microM) tested showed any effect on E-selectin expression.
Positive_regulation (attenuated) of Gene_expression (expression) of E-selectin associated with cinod, licofelone and cytokine
8) Confidence 0.36 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15894291 Disease Relevance 0.52 Pain Relevance 1.24
Gene expression of inflammatory mediators (tumor necrosis factor alpha, interleukin-1beta (IL-1beta), E-selectin (CD62E), intercellular leukocyte adhesion molecule 1, inducible nitric oxide synthase, endothelin-1) increased after surgical handling (semiquantitative RT-PCR).
Positive_regulation (increased) of Gene_expression (expression) of CD62E in leukocyte associated with necrosis, inflammatory mediators, cancer and adhesions
9) Confidence 0.25 Published 2007 Journal Basic Res. Cardiol. Section Abstract Doc Link 17268886 Disease Relevance 1.11 Pain Relevance 0.49
Expression of VCAM-1, ICAM-1, and E-selectin is induced also by cytokines such as TNF-?
Positive_regulation (induced) of Gene_expression (Expression) of E-selectin associated with cytokine
10) Confidence 0.21 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.16 Pain Relevance 0.16
levels are increased during asthma exacerbations, and this change is associated with increased expression of ICAM-1, VCAM-1, and E-selectin.37 In our present study, we found that the expression of VCAM-1 in the lung tissues was significantly decreased in the sTNFR-treatment group compared with the OVA group, suggesting that anti-inflammatory effect of sTNFR may in part be dependent on down-regulation of vascular adhesion molecules and consequent reduction of cell traffic into airway.
Positive_regulation (increased) of Gene_expression (expression) of E-selectin in lung associated with asthma, inflammation and adhesions
11) Confidence 0.17 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.12 Pain Relevance 0.24
Recent studies have shown that cytokine-induced expression of VCAM-1, ICAM-1, and E-selectin is inhibited by HDL (Cockerill et al 1995; Ashby et al 1998; Nofer et al 2003; Barter et al 2004).
Positive_regulation (induced) of Gene_expression (expression) of E-selectin associated with disorder of lipid metabolism and cytokine
12) Confidence 0.15 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.00 Pain Relevance 0.15
In the delayed endothelial response, E-selectin is expressed on endothelial cells after several hours and reaches its maximum after 12 hours [22].
Positive_regulation (response) of Gene_expression (expressed) of E-selectin in endothelial cells
13) Confidence 0.13 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.60 Pain Relevance 0.17
Of interest, this hypothermia-induced modulation towards a more procoagulant state is not based on increased expression and release of P-selectin, E-selectin, ICAM-1, VCAM-1 and GPIIb-IIIa because tissue expression and plasma levels of these markers were not affected by the reduction of the core body temperature to 34°C or 31°C.
Positive_regulation (increased) of Gene_expression (expression) of E-selectin in body associated with hypothermia
14) Confidence 0.12 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.92 Pain Relevance 0
from activated macrophages, which likely up-regulates E-selectin expression on endothelial cells to promote PMN transendothelial migration (Churg et al 2003a) and lung ECM degradation by PMN-derived serine proteinases (Figure 2).
Positive_regulation (-) of Gene_expression (expression) of E-selectin in lung
15) Confidence 0.08 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.48 Pain Relevance 0.03
E-selectin is produced by stimulated endothelium and leukocytes and P-selectin also by platelets, hence the name.
Positive_regulation (stimulated) of Gene_expression (produced) of E-selectin in platelets
16) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.55 Pain Relevance 0.12
Whereas previous studies found no effect of thrombolytic therapy with tPA or SK on circulating VCAM-1 and E-selectin during the first 24 hours after attempted reperfusion [32], we observed a gradual increase at 12-24 hours for VCAM-1 after tPA and for E-selectin after SK lysis.
Positive_regulation (during) of Gene_expression (lysis) of E-selectin
17) Confidence 0.08 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.58 Pain Relevance 0.16
Whereas previous studies found no effect of thrombolytic therapy with tPA or SK on circulating VCAM-1 and E-selectin during the first 24 hours after attempted reperfusion [32], we observed a gradual increase at 12-24 hours for VCAM-1 after tPA and for E-selectin after SK lysis.
Positive_regulation (after) of Gene_expression (lysis) of E-selectin
18) Confidence 0.08 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.50 Pain Relevance 0.15
Whereas previous studies found no effect of thrombolytic therapy with tPA or SK on circulating VCAM-1 and E-selectin during the first 24 hours after attempted reperfusion [32], we observed a gradual increase at 12-24 hours for VCAM-1 after tPA and for E-selectin after SK lysis.
Positive_regulation (for) of Gene_expression (lysis) of E-selectin
19) Confidence 0.08 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.55 Pain Relevance 0.15
Whereas previous studies found no effect of thrombolytic therapy with tPA or SK on circulating VCAM-1 and E-selectin during the first 24 hours after attempted reperfusion [32], we observed a gradual increase at 12-24 hours for VCAM-1 after tPA and for E-selectin after SK lysis.
Positive_regulation (after) of Gene_expression (lysis) of E-selectin
20) Confidence 0.08 Published 2001 Journal Crit Care Section Body Doc Link PMC31578 Disease Relevance 0.49 Pain Relevance 0.15

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