INT81886

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Context Info
Confidence 0.38
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 1.73
Pain Relevance 6.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Naa15) cytoplasm (Naa15)
Anatomy Link Frequency
brainstem 5
dorsal root ganglion 4
spinal cord 1
Naa15 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 10 100.00 Very High Very High Very High
nociceptor 6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
Inflammation 2 100.00 Very High Very High Very High
Spinal cord 15 99.68 Very High Very High Very High
intrathecal 15 99.20 Very High Very High Very High
Morphine 27 99.08 Very High Very High Very High
medulla 15 99.04 Very High Very High Very High
withdrawal 24 98.72 Very High Very High Very High
nMDA receptor 2 80.24 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 100.00 Very High Very High Very High
INFLAMMATION 2 100.00 Very High Very High Very High
Substance Withdrawal Syndrome 3 88.76 High High
Nociception 4 86.00 High High
Opiate Addiction 3 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection of eNOS antisense oligonucleotides inhibited the expression of NMDA1AR mRNA in the spinal cord of morphine-withdrawal rats, but did not in the brainstem.
Negative_regulation (inhibited) of Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine, spinal cord and intrathecal
1) Confidence 0.38 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.16 Pain Relevance 1.76
Intrathecal injection of nNOS AS-ONs significantly inhibited the increased expression of NMDA1AR mRNA in the spinal cord and brainstem of morphine-withdrawal rats.
Negative_regulation (inhibited) of Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine, spinal cord and intrathecal
2) Confidence 0.38 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.75
Decreased expression of N-methyl-D-aspartate (NMDA) receptors in rat dorsal root ganglion following complete Freund's adjuvant-induced inflammation: an immunocytochemical study for NMDA NR1 subunit.
Negative_regulation (Decreased) of Gene_expression (expression) of NMDA NR1 in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, inflammation and nociceptor
3) Confidence 0.19 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10327164 Disease Relevance 0.62 Pain Relevance 0.75
The results showed that there appeared a significant and several days-lasting down-regulation in expression of NMDA NR1 in the lumbar DRG following CFA injection, and especially, this change mainly appeared in the small and medium sized DRG neurons.
Negative_regulation (down-regulation) of Gene_expression (expression) of NMDA NR1 in DRG associated with dorsal root ganglion
4) Confidence 0.19 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10327164 Disease Relevance 0.61 Pain Relevance 0.46
Intrathecal injection of nNOS AS-ONs significantly inhibited the increased expression of NMDA1AR mRNA in the spinal cord and brainstem of morphine-withdrawal rats.
Negative_regulation (inhibited) of in spinal cord Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine, spinal cord and intrathecal
5) Confidence 0.13 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.75

General Comments

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