INT81904

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.83
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FDPS) mitochondrion (FDPS) small molecule metabolic process (FDPS)
nucleolus (FDPS) nucleus (FDPS) cytoplasm (FDPS)
Anatomy Link Frequency
plasma 2
FDPS (Homo sapiens)
Pain Link Frequency Relevance Heat
pregabalin 78 99.26 Very High Very High Very High
abdominal pain 1 89.64 High High
transdermal 3 82.56 Quite High
Angina 1 75.00 Quite High
gABA 4 73.44 Quite High
Central nervous system 4 73.12 Quite High
agonist 2 66.72 Quite High
Pain 6 36.40 Quite Low
palliative 6 20.24 Low Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 3 98.40 Very High Very High Very High
Myocardial Infarction 2 96.52 Very High Very High Very High
Anxiety Disorder 278 96.40 Very High Very High Very High
Acute Coronary Syndrome 6 95.56 Very High Very High Very High
Sleep Disorders 30 92.64 High High
Abdominal Pain 1 89.64 High High
Thrombocytopenia 1 75.92 Quite High
Intellectual Impairment 1 75.20 Quite High
Thrombosis Related Under Development 4 75.00 Quite High
Cv General 3 Under Development 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease in the platelet count and an increase in the plasma levels of thrombin-antithrombin III complex (TAT) and fibrin degradation products (FDPs) indicated the presence of subclinical intravascular coagulation.
Positive_regulation (increase) of FDPs in plasma associated with disseminated intravascular coagulation
1) Confidence 0.67 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.49 Pain Relevance 0.16
Increases in plasma concentrations of cross-linked fibrin degradation products (XL-FDPs), which reflect increased fibrin turn-over, are a marker of risk for complications of myocardial infarction.
Positive_regulation (Increases) of FDPs in plasma associated with myocardial infarction
2) Confidence 0.49 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328612 Disease Relevance 0.80 Pain Relevance 0.07
Finally, the present results again showed that diphenhydramine can be used as a sedative control substance for FPS validation studies with benzodiazepines.
Positive_regulation (substance) of FPS
3) Confidence 0.34 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.57 Pain Relevance 0.31
The lack of effect from pregabalin on any of the measures taken in the FPS experiment may possibly be related to the timing of the experiment.
Positive_regulation (experiment) of FPS associated with pregabalin
4) Confidence 0.34 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.53 Pain Relevance 0.31
Salomo and colleagues reported that BP-resistant cells had increased farnesyl pyrophosphate synthase activity, although this was not due to upregulation of its gene transcription.
Positive_regulation (increased) of pyrophosphate synthase
5) Confidence 0.16 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.24 Pain Relevance 0
Sensitivity differences to BPs may therefore result, at least in part, from increased activity of farnesyl pyrophosphate synthase [24].
Positive_regulation (increased) of pyrophosphate synthase
6) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.19 Pain Relevance 0

General Comments

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