INT81906

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Context Info
Confidence 0.20
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.06
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
plasma 4
penis 2
capillary 2
platelet 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 90.64 High High
aspirin 8 90.24 High High
Paracetamol 3 88.68 High High
Angina 4 87.28 High High
antagonist 1 86.16 High High
cytokine 1 80.44 Quite High
fibrosis 1 78.32 Quite High
cva 1 71.28 Quite High
Pain 1 59.48 Quite High
vincristine 1 50.16 Quite High
Disease Link Frequency Relevance Heat
Necrosis 14 100.00 Very High Very High Very High
Disease 10 99.92 Very High Very High Very High
Thrombosis 30 99.76 Very High Very High Very High
Injury 3 99.04 Very High Very High Very High
Dyspnea 4 96.88 Very High Very High Very High
Acute Coronary Syndrome 10 95.56 Very High Very High Very High
Myocardial Infarction 4 95.32 Very High Very High Very High
Sepsis 15 93.60 High High
Cancer 4 92.84 High High
Coagulation Disorder 1 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, LPS-induced thrombin generation increased plasma levels of circulating polymerized, but not cross-linked, fibrin (ie, thrombus precursor protein), whereas levels of soluble fibrin were unaffected.
Positive_regulation (increased) of fibrin Neg (not) Binding (cross-linked) of in plasma associated with thrombosis
1) Confidence 0.20 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.15 Pain Relevance 0.49
Increases in plasma concentrations of cross-linked fibrin degradation products (XL-FDPs), which reflect increased fibrin turn-over, are a marker of risk for complications of myocardial infarction.
Positive_regulation (Increases) of fibrin Binding (cross-linked) of in plasma associated with myocardial infarction
2) Confidence 0.12 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328612 Disease Relevance 0.79 Pain Relevance 0.07
Thus, even an impairment of capillary perfusion as a result of augmented fibrin clot formation after the administration of this procoagulative substance is conceivable.
Positive_regulation (augmented) of fibrin Binding (formation) of in capillary
3) Confidence 0.09 Published 2006 Journal Crit Care Section Body Doc Link PMC1550842 Disease Relevance 0.48 Pain Relevance 0
In contrast, other studies have shown that the formation of fibrin is dependent upon the shear rate, with lower shear rates supporting more fibrin generation [14], [15].
Positive_regulation (dependent) of fibrin Binding (formation) of
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2861630 Disease Relevance 0.20 Pain Relevance 0
Casein zymography revealed an ACP-dependent decrease in fibrin binding of a low molecular weight (Mw) protease triplet (47-, 43-, 42-kDa) and increased fibrin binding of two high Mw proteases (94- and 84-kDa).
Positive_regulation (increased) of fibrin Binding (binding) of
5) Confidence 0.02 Published 2001 Journal Inflammation Section Abstract Doc Link 11820459 Disease Relevance 0.15 Pain Relevance 0.16
Tissue factor emerges as the initial mechanism leading to thrombin generation and fibrin formation to stabilize the platelet-rich thrombus.
Positive_regulation (leading) of fibrin Binding (formation) of in platelet associated with thrombosis
6) Confidence 0.01 Published 2004 Journal Rev Clin Esp Section Abstract Doc Link 15104934 Disease Relevance 0.87 Pain Relevance 0.17
Injury to the erect penis is thought to trigger PD by inducing extravasation of fibrin and subsequent synthesis of transforming-growth-factor beta1.
Positive_regulation (inducing) of fibrin Binding (extravasation) of in penis associated with injury and disease
7) Confidence 0.01 Published 2005 Journal Nature clinical practice. Urology Section Abstract Doc Link 16474811 Disease Relevance 1.35 Pain Relevance 0.14
Cross-linked fibrin degradation products (D-dimer) were also high just after the onset of BMN and continued to be high for 3 weeks after the onset.
Positive_regulation (high) of fibrin Binding (Cross-linked) of associated with necrosis
8) Confidence 0.00 Published 2002 Journal Am. J. Hematol. Section Abstract Doc Link 12111773 Disease Relevance 2.06 Pain Relevance 0.12

General Comments

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