INT81915

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL1B) protein complex (HSF1) cell-cell signaling (IL1B)
cytoplasm (HSF1) cytosol (IL1B) extracellular space (IL1B)
Anatomy Link Frequency
THP-1 1
HSF1 (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 97.00 Very High Very High Very High
cytokine 2 75.00 Quite High
Inflammatory stimuli 1 58.16 Quite High
Disease Link Frequency Relevance Heat
Shock 5 100.00 Very High Very High Very High
INFLAMMATION 3 94.76 High High
Repression 1 50.80 Quite High
Stress 2 26.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As HSF1 can function as both an activator of heat shock genes and a repressor of non-heat shock genes such as IL1B and c- fos, we have examined the potential role of HSF1 in the effects of NSAIDs on gene expression in a human monocytic cell line THP-1.
HSF1 Negative_regulation (repressor) of IL1B in THP-1 associated with shock and cinod
1) Confidence 0.51 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.65 Pain Relevance 0.59

General Comments

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