INT81922

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.25
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B2P) protein folding (HSP90B2P) response to stress (HSP90B2P)
HSP90B2P (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 99.70 Very High Very High Very High
monoamine 1 97.04 Very High Very High Very High
tolerance 23 96.88 Very High Very High Very High
Inflammation 11 90.12 High High
Inflammatory stimuli 1 87.44 High High
Arthritis 2 82.72 Quite High
Hyperalgesia 1 81.72 Quite High
cytokine 11 75.00 Quite High
IPN 1 72.92 Quite High
ischemia 2 60.00 Quite High
Disease Link Frequency Relevance Heat
Stress 52 99.84 Very High Very High Very High
Skin Cancer 16 99.46 Very High Very High Very High
Insulin Resistance 11 98.16 Very High Very High Very High
Impaired Glucose Tolerance 22 96.88 Very High Very High Very High
Diabetes Mellitus 31 95.88 Very High Very High Very High
Aging 26 92.80 High High
Apoptosis 3 90.68 High High
Repression 1 90.68 High High
INFLAMMATION 16 90.12 High High
Cancer 46 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, SQDB was found to induce intestinal microflora which, in turn, altered HSP gene expression [30].
Regulation (altered) of Gene_expression (expression) of HSP
1) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825258 Disease Relevance 0.79 Pain Relevance 0.29
Additionally, there is evidence of post-transcriptional regulation of HSP production [34].
Regulation (regulation) of Gene_expression (production) of HSP
2) Confidence 0.05 Published 2003 Journal Crit Care Section Body Doc Link PMC270667 Disease Relevance 0.77 Pain Relevance 0
Strategies to decrease oxidative stress and to modulate HSP expression may have important implications for reducing insulin resistance and increasing the protection against diabetes and its complications.
Regulation (modulate) of Gene_expression (expression) of HSP associated with stress, diabetes mellitus and insulin resistance
3) Confidence 0.04 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2330145 Disease Relevance 1.00 Pain Relevance 0.12
Exposure to NSAIDs had a complex effect on HSP gene expression and while sulindac activated the stress responsive HSP70B promoter, sodium salicylate did not.
Regulation (effect) of Gene_expression (expression) of HSP gene associated with stress and cinod
4) Confidence 0.03 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.75 Pain Relevance 0.91
In vitro studies in melanoma cells showed the level of HSP expression to be dependent on time and temperature, with the maximal rate of synthesis at 42°C and 9 hours exposure reaching a steady state with levels not much higher than constitutive expression following continued exposure [31].
Regulation (dependent) of Gene_expression (expression) of HSP associated with skin cancer
5) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2903950 Disease Relevance 0.95 Pain Relevance 0.03

General Comments

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