INT81923

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 11 99.34 Very High Very High Very High
Inflammatory stimuli 1 81.44 Quite High
cytokine 2 75.00 Quite High
addiction 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 28 100.00 Very High Very High Very High
Stress 22 99.16 Very High Very High Very High
INFLAMMATION 4 81.88 Quite High
Repression 1 74.08 Quite High
Toxicity 4 45.12 Quite Low
Apoptosis 11 44.08 Quite Low
Death 9 27.36 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Nicotine Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that two members of the NSAIDs, sodium salicylate and sulindac repress the IL1B promoter to similar degree to heat shock or HSF1 overexpression.
Negative_regulation (repress) of Gene_expression (overexpression) of HSF1 associated with shock and cinod
1) Confidence 0.42 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.68 Pain Relevance 0.73
To assess the importance of the heat shock response in mediating the cellular response to electrophile stress, siRNA was used to silence HSF1, thereby attenuating heat shock gene expression in HNE-treated cells.(27) Control and HSF1-deficient cells were then exposed to HNE, and various responses measured including viability and gene expression changes. siRNA knockdown of HSF1 was nearly complete, and residual expression of the transcription factor was vanishingly small.
Negative_regulation (attenuating) of Gene_expression (expression) of HSF1 associated with stress and shock
2) Confidence 0.36 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.50 Pain Relevance 0

General Comments

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