INT81926

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.05
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (HSF1) nucleus (HSF1) protein complex (HSF1)
cytoplasm (HSF1)
Anatomy Link Frequency
fibroblasts 1
HSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 25 99.12 Very High Very High Very High
Spinal cord 36 89.52 High High
rheumatoid arthritis 32 86.68 High High
Immobilon 6 83.52 Quite High
Inflammatory stimuli 2 78.04 Quite High
cytokine 16 75.00 Quite High
Arthritis 7 63.20 Quite High
Migraine 46 50.00 Quite Low
Inflammation 13 41.76 Quite Low
metalloproteinase 3 27.20 Quite Low
Disease Link Frequency Relevance Heat
Shock 291 99.54 Very High Very High Very High
INFLAMMATION 21 98.84 Very High Very High Very High
Stress 184 97.68 Very High Very High Very High
Rheumatoid Arthritis 32 86.68 High High
Repression 2 81.28 Quite High
Neuroblastoma 1 80.60 Quite High
Arthritis 6 63.20 Quite High
Heat Stress Disorders 8 55.04 Quite High
Hyperplasia 1 54.92 Quite High
Headache 45 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings reflect the properties of HSF1 which can be activated to at least two DNA binding forms only one of which activates heat shock promoters and suggest that individual NSAID family members may differentially induce one or other of these forms.
HSF1 Binding (binding) of associated with shock and cinod
1) Confidence 0.47 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.60 Pain Relevance 0.80
HNE treatment has been shown in vitro to adduct specific amino acid residues on both Hsp70 and Hsp90, which correlates with their reduced ability to bind and properly fold client proteins.28,29 We performed coimmunoprecipitation experiments with myc-tagged Hsp70, demonstrating that its association with HSF1 is disrupted by HNE treatment.
HSF1 Binding (association) of
2) Confidence 0.41 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.72 Pain Relevance 0
We are presently determining the sites of Hsp90 and Hsp70 modification and the functional consequences of HNE modification both in terms of HSF1 binding as well as its affiliation with other specific client proteins.
HSF1 Binding (binding) of
3) Confidence 0.41 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.54 Pain Relevance 0
Samples were subjected to SDS-PAGE (4–12% acrylamide gel) followed by immuno-Western blot probing for HSF1 as described above.
HSF1 Binding (probing) of
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0 Pain Relevance 0.07
Recent studies have shown that the non-steroidal anti-inflammatory drugs (NSAIDs) activate heat shock transcription factor (HSF1) from a latent cytoplasmic form to a nuclear, DNA binding state.
HSF1 Binding (binding) of associated with inflammation, shock and cinod
5) Confidence 0.35 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.53 Pain Relevance 0.53
These considerations suggest that both the basal (37°C) and the heat shock-induced (42°C) hsp70-reporter gene activity is an accurate and valid assessment of the activity of HSF1-an activity which includes the trimerization and nuclear translocation of HSF1 and binding of the HSF1 trimer to the heat shock element to transactivate the hsp70 promoter [18].
HSF1 Binding (binding) of associated with shock
6) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.49 Pain Relevance 0
HSF1 mediates the HSR: stress acutely converts the constitutively expressed dormant, monomeric HSF1 in the cytosol to a nuclear localized, hyperphosphorylated HSF1 trimer that binds and trans-activates the heat shock promoters [18].
HSF1 Binding (binds) of associated with stress and shock
7) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481402 Disease Relevance 0.39 Pain Relevance 0.04
We are presently determining the sites of Hsp90 and Hsp70 modification and the functional consequences of HNE modification both in terms of HSF1 binding as well as its affiliation with other specific client proteins.
HSF1 Binding (affiliation) of
8) Confidence 0.32 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.54 Pain Relevance 0
Moreover, to determine if HSF1 is one of the transcription factors bound to the complexes, anti-HSF1 antibody was used in super shift assays.
HSF1 Binding (bound) of
9) Confidence 0.23 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.14 Pain Relevance 0
Interestingly, recent data from our laboratory have shown that shear stress induces a complete response of the heat shock factor (HSF)-1/HSP70 pathway in synovial fibroblasts by inducing DNA binding of HSF-1 (Fig. 1) and the subsequent overexpression of HSP70 [11].
HSF-1 Binding (binding) of in fibroblasts associated with stress and shock
10) Confidence 0.08 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.10 Pain Relevance 0.07

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