INT81929

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 27.99
Pain Relevance 9.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
monocytes 8
blood 7
chondrocytes 6
plasma 4
T cells 4
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 880 100.00 Very High Very High Very High
Inflammation 818 100.00 Very High Very High Very High
Inflammatory response 59 99.36 Very High Very High Very High
Angina 6 99.28 Very High Very High Very High
Arthritis 369 99.20 Very High Very High Very High
cINOD 35 99.04 Very High Very High Very High
Inflammatory stimuli 8 98.36 Very High Very High Very High
Osteoarthritis 111 98.24 Very High Very High Very High
chemokine 111 97.16 Very High Very High Very High
ischemia 5 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 1266 100.00 Very High Very High Very High
INFLAMMATION 900 100.00 Very High Very High Very High
Shock 52 99.86 Very High Very High Very High
Cancer 205 99.80 Very High Very High Very High
Necrosis 53 99.56 Very High Very High Very High
Disease 377 99.40 Very High Very High Very High
Inflammatory Bowel Disease 35 99.32 Very High Very High Very High
Hypertension 9 99.28 Very High Very High Very High
Cv General 3 Under Development 7 99.28 Very High Very High Very High
Juvenile Chronic Polyarthritis 302 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M. vaccae administration has also been shown to facilitate the development of Treg cells that can downregulate Th2 immune responses via production of interleukin-10 (IL-10) and transforming growth factor-?
Negative_regulation (downregulate) of Gene_expression (production) of interleukin-10
1) Confidence 0.57 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.26 Pain Relevance 0.12
Experimental studies have indicated that sampling time may considerably influence IL-10 measurements; IL-10 production was delayed in a study of patients measured before and after percutaneous coronary intervention and in vitro the production of IL-10 in lipopolysacharide-stimulated monocytes is delayed compared with that of interleukin-1?
Negative_regulation (delayed) of Gene_expression (production) of IL-10 in monocytes
2) Confidence 0.43 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.65 Pain Relevance 0.10
Experimental studies have indicated that sampling time may considerably influence IL-10 measurements; IL-10 production was delayed in a study of patients measured before and after percutaneous coronary intervention and in vitro the production of IL-10 in lipopolysacharide-stimulated monocytes is delayed compared with that of interleukin-1?
Negative_regulation (delayed) of Gene_expression (production) of IL-10 in monocytes
3) Confidence 0.43 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.64 Pain Relevance 0.09
Serum levels of the antiinflammatory cytokine interleukin-10 are decreased in patients with unstable angina.
Negative_regulation (decreased) of Gene_expression (levels) of antiinflammatory cytokine interleukin-10 associated with angina, inflammation and cytokine
4) Confidence 0.43 Published 2001 Journal Circulation Section Title Doc Link 11502695 Disease Relevance 0.48 Pain Relevance 0.33
Interestingly, the amount of IL10-producing Tr1 cells, shown to be critical for the control of “determinant spreading“ during chronic immune responses [27], was found drastically reduced in TLT.
Negative_regulation (reduced) of Gene_expression (producing) of IL10 in Tr1 cells
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0.09 Pain Relevance 0.05
Extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes

Background

Negative_regulation (down) of Gene_expression (expression) of interleukin-10 in chondrocytes associated with necrosis, cancer, shock and osteoarthritis
6) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Title Doc Link PMC2268688 Disease Relevance 0.89 Pain Relevance 0.08
Extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes

Background

Negative_regulation (regulate) of Gene_expression (expression) of interleukin-10 in chondrocytes associated with necrosis, cancer, shock and osteoarthritis
7) Confidence 0.33 Published 2008 Journal BMC Musculoskelet Disord Section Title Doc Link PMC2268688 Disease Relevance 0.89 Pain Relevance 0.08
IL-10 expression significantly decreased in chondrocytes treated with all levels of energy and impulses, while TNF-alpha seemed to be selectively reduced at middle levels.
Negative_regulation (decreased) of Gene_expression (expression) of IL-10 in chondrocytes
8) Confidence 0.32 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.26 Pain Relevance 0.13
Similarly, clinically relevant doses of hypertonic saline in vitro were found to suppress IL-10 production in isolated LPS-stimulated human ??
Negative_regulation (suppress) of Gene_expression (production) of IL-10
9) Confidence 0.29 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.86 Pain Relevance 0.07
and IL-6 together with a less pronounced decrease in IL-10 production.
Negative_regulation (decrease) of Gene_expression (production) of IL-10
10) Confidence 0.27 Published 2005 Journal Crit Care Section Abstract Doc Link PMC1297621 Disease Relevance 0.40 Pain Relevance 0.38
and IL-6 together with a less pronounced decrease in IL-10 production.
Negative_regulation (decrease) of Gene_expression (production) of IL-10
11) Confidence 0.27 Published 2005 Journal Crit Care Section Body Doc Link PMC1297621 Disease Relevance 0.78 Pain Relevance 0.39
Similarly, they suppressed LPS-stimulated IL-10 and IL-12 production in THP-1 matured to monocytes by 1alpha,25-dihydroxyvitamin D3.
Negative_regulation (suppressed) of Gene_expression (production) of IL-10 in monocytes
12) Confidence 0.27 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.16
Endomorphins 1 and 2 inhibited lipopolysaccharide (LPS)-stimulated IL-10 and IL-12 production in THP-1 differentiated to macrophage-like cells by phorbol 12-myristate 13-acetate (PMA).
Negative_regulation (inhibited) of Gene_expression (production) of IL-10 in THP-1
13) Confidence 0.27 Published 2002 Journal Scand. J. Immunol. Section Abstract Doc Link 12193227 Disease Relevance 0 Pain Relevance 0.14
Our results, in contrast, show that in newborn infants the ex vivo production of IL-10 was decreased 5 days after the operation, even though not significantly in comparison with preoperative values.
Negative_regulation (decreased) of Gene_expression (production) of IL-10
14) Confidence 0.27 Published 2005 Journal Crit Care Section Body Doc Link PMC1297621 Disease Relevance 0.43 Pain Relevance 0.37
downregulators in the treatment of genetically low IL-10/high TNF?
Negative_regulation (downregulators) of Gene_expression (high) of IL-10
15) Confidence 0.26 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526590 Disease Relevance 0.91 Pain Relevance 0.21
Negligible decline in plasma IL-12 and IL-10 levels, negligible elevation of IFN-?
Negative_regulation (decline) of Gene_expression (levels) of IL-10 in plasma
16) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.17 Pain Relevance 0.04
activity may be related to the simultaneous presence of elevated levels of IL-10 and TGF-?
Negative_regulation (presence) of Gene_expression (levels) of IL-10
17) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.74 Pain Relevance 0.20
Successfully cured patients showed reduced IL-12 and IL-10 levels in the plasma and two-fold or more increase in Th1 type-cytokines IFN-?
Negative_regulation (reduced) of Gene_expression (levels) of IL-10 in plasma associated with cytokine
18) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2910702 Disease Relevance 0.73 Pain Relevance 0.17
When exposed to both IL-10 and HC, the levels were further reduced.


Negative_regulation (reduced) of Gene_expression (exposed) of IL-10
19) Confidence 0.22 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.13
IL-10 is not a factor for the inhibition of TNF or for IL-6 production.
Negative_regulation (inhibition) of Gene_expression (production) of IL-10
20) Confidence 0.21 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18349186 Disease Relevance 0 Pain Relevance 0

General Comments

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