INT81942

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Context Info
Confidence 0.29
First Reported 1999
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.43
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
spike 2
limb muscles 1
myotubes 1
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 3 100.00 Very High Very High Very High
addiction 2 85.20 High High
tetrodotoxin 6 67.20 Quite High
Neuropeptide 5 50.00 Quite Low
adenocard 1 25.00 Low Low
fibrosis 4 14.00 Low Low
cytokine 14 12.36 Low Low
Central nervous system 3 9.76 Low Low
Calcium channel 12 5.00 Very Low Very Low Very Low
Cholecystokinin 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 30 76.24 Quite High
Disease 112 74.16 Quite High
Stress 52 73.84 Quite High
Bacillus Anthracis Infection 28 50.00 Quite Low
Body Weight 5 37.48 Quite Low
Infection 17 21.36 Low Low
Fibrosis 4 14.00 Low Low
Frailty 1 9.76 Low Low
Pressure And Volume Under Development 14 9.00 Low Low
Toxicity 2 8.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results depicted unchanged peak and resting intracellular Ca2+, as well as intracellular Ca2+ decay rate (?)
Neg (unchanged) Regulation (depicted) of Neg (unchanged) Regulation (unchanged) of Ca2
1) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.15 Pain Relevance 0
Our results depicted unchanged peak and resting intracellular Ca2+, as well as intracellular Ca2+ decay rate (?)
Neg (unchanged) Regulation (depicted) of Regulation (intracellular) of Ca2
2) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.15 Pain Relevance 0
The present study used real-time confocal microscopy to examine the effects of the beta2-adrenoceptor agonist salbutamol on regulation of intracellular Ca2+ concentration ([Ca2+]i) in myotubes derived from neonatal mouse limb muscles.
Spec (examine) Regulation (effects) of in myotubes Spec (examine) Regulation (regulation) of Ca2 in limb muscles associated with agonist
3) Confidence 0.23 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10329950 Disease Relevance 0 Pain Relevance 0.12
The observed transient increase in spike frequency or its oscillation may thus result from the superposition of two contrary effects on pacemaking, namely the up-regulation of voltage-gated Ca2+ currents on the one hand and the down-regulation of the Ca2+ background current on the other.
Regulation (regulation) of Regulation (regulation) of Ca2 in spike
4) Confidence 0.09 Published 2007 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2525928 Disease Relevance 0 Pain Relevance 0
Intestinal Ca2+ absorption is a crucial control system in the regulation of Ca2+ homeostasis because it facilitates the entry of dietary Ca2+ into the extracellular compartment.
Regulation (control) of Regulation (regulation) of Ca2
5) Confidence 0.07 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2045662 Disease Relevance 0 Pain Relevance 0
Our results revealed downregulated SERCA in conjunction with upregulated phospholamban, an endogenous inhibitor of SERCA, following in vitro lethal toxin exposure, favoring a likely role of SERCA/phospholamban in lethal toxin-induced intracellular Ca2+ dysregulation.
Spec (likely) Regulation (role) of Spec (likely) Regulation (dysregulation) of Ca2
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954163 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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