INT81945

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.55
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
liver 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bioavailability 2 100.00 Very High Very High Very High
Paracetamol 12 99.82 Very High Very High Very High
antagonist 5 7.32 Low Low
cerebral cortex 9 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyslipidemia /

Combined Dyslipidemia

14 99.88 Very High Very High Very High
Toxicity 4 83.56 Quite High
Hepatotoxicity 3 75.60 Quite High
Repression 2 66.92 Quite High
Apoptosis 74 63.28 Quite High
Increased Venous Pressure Under Development 22 58.52 Quite High
Suicidal Behaviour 27 50.00 Quite Low
Hyperlipidemia 4 19.44 Low Low
Disorder Of Lipid Metabolism 33 13.40 Low Low
Death 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Absorption and bioavailability of the combination of niacin ER and simvastatin
Negative_regulation (Absorption) of ER Binding (combination) of associated with bioavailability
1) Confidence 0.32 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.13 Pain Relevance 0.10
While our data indicates that estrogen suppresses the expression of p53-induced proteins like Bax [37] and Fas, other data indicates that p53 can suppress estrogen receptor activation [85], by preventing ER-alpha binding to EREs.
Negative_regulation (preventing) of ER-alpha Binding (binding) of
2) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.24 Pain Relevance 0
Estrogen receptor-binding assays demonstrated that acetaminophen did not reduce binding of [3H]-estradiol to trout liver estrogen receptor.
Neg (not) Negative_regulation (reduce) of estrogen receptor Binding (binding) of in liver associated with paracetamol
3) Confidence 0.02 Published 1999 Journal Toxicol. Sci. Section Abstract Doc Link 10330681 Disease Relevance 0.08 Pain Relevance 0.96

General Comments

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