INT81965

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 21
Disease Relevance 13.29
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F5) extracellular region (F5) cell adhesion (F5)
plasma membrane (F5)
Anatomy Link Frequency
Placenta 2
neurons 1
platelets 1
F5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 33 94.28 High High
Spinal cord 2 89.40 High High
antagonist 1 88.24 High High
Pain 14 87.68 High High
Inflammation 12 76.76 Quite High
rheumatoid arthritis 3 76.16 Quite High
fibrosis 4 75.44 Quite High
beta blocker 2 54.24 Quite High
cytokine 5 34.16 Quite Low
Central nervous system 1 19.56 Low Low
Disease Link Frequency Relevance Heat
Abruptio Placentae 189 99.68 Very High Very High Very High
Thrombosis 63 99.62 Very High Very High Very High
Eclampsia 306 99.52 Very High Very High Very High
Togavirus Infection 738 99.16 Very High Very High Very High
Birth Weight 72 99.16 Very High Very High Very High
Anaemia 15 98.62 Very High Very High Very High
Pregnancy Complications 216 98.12 Very High Very High Very High
Inflammatory Bowel Disease 43 97.88 Very High Very High Very High
Systemic Lupus Erythematosus 3 96.04 Very High Very High Very High
Hemorrhage 15 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obviously, additional acquired or inherited risk factors may increase individual predisposition to thrombosis; genetically, the Factor V Leiden mutation and the 677 C>T methylenetetrahydrofolate reductase gene variant (as well as MTHFR polymorphisms leading to hyperhomocysteinemia) may have a relevant role, although this has not been proven so far (Nafa et al 1996).
Gene_expression (mutation) of Factor V Leiden associated with hyperhomocysteinemia and thrombosis
1) Confidence 0.65 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 1.15 Pain Relevance 0
2-glycoprotein I antibodies, factor II G20210A mutation, factor V Leiden mutation, anti-thrombin, protein C and protein S) showed low level of free protein S antigen (37% normal > 55%).
Gene_expression (mutation) of factor V Leiden
2) Confidence 0.65 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2836274 Disease Relevance 1.60 Pain Relevance 0.15
Maternal FVL/PGM and Pre-eclampsia
Gene_expression (/) of FVL associated with eclampsia
3) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.49 Pain Relevance 0
Maternal FVL/PGM and Severe SGA Neonate (Birth Weight <5th Percentile)
Gene_expression (/) of FVL associated with birth weight
4) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.19 Pain Relevance 0
Maternal FVL/PGM and Pregnancy Loss
Gene_expression (/) of FVL
5) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.15 Pain Relevance 0
Maternal FVL/PGM and the Composite of Any Placenta-Mediated Pregnancy Complications
Gene_expression (/) of FVL in Placenta associated with pregnancy complications
6) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.84 Pain Relevance 0
Maternal FVL/PGM and the Composite of Any Placenta-Mediated Pregnancy Complications
Gene_expression (Maternal) of FVL in Placenta associated with pregnancy complications
7) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.84 Pain Relevance 0
The combined OR for this population showed no significant association between FVL status and SGA <5th percentile (pooled OR?
Gene_expression (status) of FVL
8) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.24 Pain Relevance 0
Maternal FVL/PGM and Placental Abruption
Gene_expression (/) of FVL associated with abruptio placentae
9) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.37 Pain Relevance 0
Maternal FVL/PGM and SGA Neonate (Birth Weight <10th Percentile)
Gene_expression (/) of FVL associated with birth weight
10) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.73 Pain Relevance 0
1.23, 95% CI 0.89–1.70) or between FVL and SGA (OR?
Gene_expression (between) of FVL
11) Confidence 0.58 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.79 Pain Relevance 0
Heterozygous factor V Leiden mutation was found in two of the eight infants without central venous catheter.
Neg (without) Gene_expression (found) of factor V Leiden mutation
12) Confidence 0.58 Published 1999 Journal Eur. J. Pediatr. Section Abstract Doc Link 10333128 Disease Relevance 0.78 Pain Relevance 0.05
The F5 PTNs we recorded were found in the same region of area F5 as in the original report by Gallese et al. (1996) and were mostly located on the convexity of the gyrus, as predicted from retrograde labeling of corticospinal neurons (He et al., 1993).
Gene_expression (found) of F5 in neurons
13) Confidence 0.19 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0 Pain Relevance 0.04
An increased frequency of Factor V Leiden, antithrombin deficiency and the prothrombin (G20210A) gene mutation have not been consistently identified [1].
Gene_expression (deficiency) of Factor V
14) Confidence 0.13 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.90 Pain Relevance 0.11
Stable cell lines producing F5 nIgG were established by selecting transfected 293-EBNA cells with puromycin (10µg/ml).
Gene_expression (producing) of F5 nIgG
15) Confidence 0.10 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.06 Pain Relevance 0
Additionally, there was no competition between F5 and anti-E2g or anti-E2h mMAbs.
Gene_expression (mMAbs) of F5
16) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.33 Pain Relevance 0
4000-fold more Hy4 IgG than the parent virus for neutralization, and thus was neutralization-resistant for both F5 nIgG and Hy4 IgG.
Gene_expression (resistant) of F5 nIgG
17) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.32 Pain Relevance 0
The vF5-5 virus required ?
Gene_expression (virus) of vF5-5
18) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.38 Pain Relevance 0
F5 Fab was expressed as a complete IgG1 molecule, F5 native (n) IgG.
Gene_expression (expressed) of F5
19) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2903468 Disease Relevance 0.88 Pain Relevance 0
Because the P3F5 clone had significant VEEV-neutralizing ability, a stable cell line expressing F5 nIgG was generated in 293-EBNA cells.
Gene_expression (expressing) of F5 nIgG associated with togavirus infection
20) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.52 Pain Relevance 0

General Comments

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