INT81968

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Context Info
Confidence 0.07
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLEK, Adra2a) cytosol (PLEK) signal transduction (Adra2a)
extracellular region (PLEK) plasma membrane (Adra2a) signal transducer activity (Adra2a)
Anatomy Link Frequency
platelet 1
PLEK (Homo sapiens)
Adra2a (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 9 98.00 Very High Very High Very High
depression 2 97.04 Very High Very High Very High
agonist 3 96.32 Very High Very High Very High
antagonist 2 53.36 Quite High
Disease Link Frequency Relevance Heat
Depression 2 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, few studies have investigated the relative distribution of alpha2AR between the high- and low-affinity states or their Gi protein coupling. [3H]yohimbine saturable binding to platelet alpha2AR, its displacement by norepinephrine and clonidine, and the effects of Gpp(NH)p on agonist displacement curves were investigated in 11 healthy volunteers.
platelet Binding (binding) of alpha2AR in platelet associated with agonist and clonidine
1) Confidence 0.07 Published 1999 Journal Psychiatry Res Section Abstract Doc Link 10333382 Disease Relevance 0.10 Pain Relevance 0.70

General Comments

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