INT81976

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Context Info
Confidence 0.02
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GNA15, OPRL1) signal transducer activity (GNA15, OPRL1) signal transduction (GNA15)
GTPase activity (GNA15)
GNA15 (Homo sapiens)
OPRL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
orphanin 2 100.00 Very High Very High Very High
Kappa opioid receptor 2 99.66 Very High Very High Very High
opioid receptor 4 97.08 Very High Very High Very High
imagery 4 86.08 High High
Opioid 2 79.92 Quite High
agonist 2 78.40 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that the mu, delta, and kappa opioid receptors and the related nociceptin receptor, ORL1, each couple to Galphaqi5, Galphaqo5, and Galpha16 (Galphaqi5 and Galphaqo5 refer to Galphaq proteins containing the five carboxyl-terminal amino acids from Galphai and Galphao, respectively) and that different receptor/G protein combinations show different levels of maximal activation.
Galpha16 Binding (couple) of ORL1 associated with orphanin and kappa opioid receptor
1) Confidence 0.02 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10334841 Disease Relevance 0 Pain Relevance 0.38
We show that the mu, delta, and kappa opioid receptors and the related nociceptin receptor, ORL1, each couple to Galphaqi5, Galphaqo5, and Galpha16 (Galphaqi5 and Galphaqo5 refer to Galphaq proteins containing the five carboxyl-terminal amino acids from Galphai and Galphao, respectively) and that different receptor/G protein combinations show different levels of maximal activation.
Galpha16 Binding (couple) of nociceptin receptor associated with orphanin and kappa opioid receptor
2) Confidence 0.02 Published 1999 Journal Anal. Biochem. Section Abstract Doc Link 10334841 Disease Relevance 0 Pain Relevance 0.39

General Comments

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