INT81981

Context Info Confidence 0.27 First Reported 1999 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.88 Pain Relevance 0.21

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)

Anatomy Link Frequency spinal 1 Bmpr2 (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 1 99.56 COX-2 inhibitor 1 96.56 Pain 2 64.64 COX2 1 25.00 Inflammation 11 5.00 cytokine 4 5.00 antagonist 2 5.00 imagery 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 3 99.84 Cancer 61 99.28 INFLAMMATION 12 98.84 Prostate Cancer 6 98.24 Metastasis 12 97.16 Osteoporosis 6 94.52 Recurrence 1 93.92 Melanoma 5 90.76 Adenocarcinoma 2 79.88 Colon Cancer 7 78.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The stimulatory effect of BMP-2 was abolished by adding nonsteroidal anti-inflammatory drugs, such as indomethacin and a selective COX-2 inhibitor NS-398.

Negative_regulation (abolished) of BMP-2 associated with inflammation, cinod and cox-2 inhibitor

1) Confidence 0.27 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10334922 Disease Relevance 0.51 Pain Relevance 0.15

On the other hand, the mRNA level of BMP-2 was significantly decreased in breast cancer tumors compared to normal breast tissue [47]. 2.2.3.

Negative_regulation (decreased) of BMP-2 associated with cancer and breast cancer

2) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.09 Pain Relevance 0

Medium was then exchanged with medium containing defined amounts of extract respectively recombinant human BMP-2 [10] and BMP-7 (Stryker Biotech, Hopkinton, MA, USA) standards, plus 10 ?

Negative_regulation (recombinant) of BMP-2

3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0 Pain Relevance 0

Specific guidelines for rhBMP-2 and rhBMP-7 use are lacking because of the limited availability of randomized controlled clinical trials and its diverse use in many spinal applications.

Negative_regulation (lacking) of rhBMP-2 in spinal

4) Confidence 0.01 Published 2008 Journal Neurosurgery Section Abstract Doc Link 18596525 Disease Relevance 0.27 Pain Relevance 0.06

General Comments

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