INT81981

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Context Info
Confidence 0.27
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.88
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
spinal 1
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 99.56 Very High Very High Very High
COX-2 inhibitor 1 96.56 Very High Very High Very High
Pain 2 64.64 Quite High
COX2 1 25.00 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 3 99.84 Very High Very High Very High
Cancer 61 99.28 Very High Very High Very High
INFLAMMATION 12 98.84 Very High Very High Very High
Prostate Cancer 6 98.24 Very High Very High Very High
Metastasis 12 97.16 Very High Very High Very High
Osteoporosis 6 94.52 High High
Recurrence 1 93.92 High High
Melanoma 5 90.76 High High
Adenocarcinoma 2 79.88 Quite High
Colon Cancer 7 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The stimulatory effect of BMP-2 was abolished by adding nonsteroidal anti-inflammatory drugs, such as indomethacin and a selective COX-2 inhibitor NS-398.
Negative_regulation (abolished) of BMP-2 associated with inflammation, cinod and cox-2 inhibitor
1) Confidence 0.27 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10334922 Disease Relevance 0.51 Pain Relevance 0.15
On the other hand, the mRNA level of BMP-2 was significantly decreased in breast cancer tumors compared to normal breast tissue [47].

2.2.3.

Negative_regulation (decreased) of BMP-2 associated with cancer and breast cancer
2) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 2.09 Pain Relevance 0
Medium was then exchanged with medium containing defined amounts of extract respectively recombinant human BMP-2 [10] and BMP-7 (Stryker Biotech, Hopkinton, MA, USA) standards, plus 10 ?
Negative_regulation (recombinant) of BMP-2
3) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779385 Disease Relevance 0 Pain Relevance 0
Specific guidelines for rhBMP-2 and rhBMP-7 use are lacking because of the limited availability of randomized controlled clinical trials and its diverse use in many spinal applications.
Negative_regulation (lacking) of rhBMP-2 in spinal
4) Confidence 0.01 Published 2008 Journal Neurosurgery Section Abstract Doc Link 18596525 Disease Relevance 0.27 Pain Relevance 0.06

General Comments

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