INT81982

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 36
Total Number 37
Disease Relevance 14.58
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
bone marrow 2
PC-3 2
quadriceps 1
chondrocytes 1
embryos 1
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 55 98.76 Very High Very High Very High
Inflammation 237 96.12 Very High Very High Very High
Neurotransmitter 4 91.60 High High
Osteoarthritis 215 87.52 High High
cytokine 108 85.04 High High
Intracerebroventricular 8 80.80 Quite High
backache 3 77.00 Quite High
rheumatoid arthritis 35 72.32 Quite High
cINOD 53 71.20 Quite High
COX-2 inhibitor 1 65.20 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 209 99.84 Very High Very High Very High
Cancer 409 99.80 Very High Very High Very High
Targeted Disruption 33 99.44 Very High Very High Very High
Osteogenic Sarcomas 21 99.28 Very High Very High Very High
Arthritis 33 99.22 Very High Very High Very High
Alzheimer's Dementia 2 99.08 Very High Very High Very High
Malignant Neoplastic Disease 48 99.00 Very High Very High Very High
Fracture Healing 230 98.98 Very High Very High Very High
Reprotox - General 1 54 98.80 Very High Very High Very High
Transitional Cell Carcinoma 3 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injections of cells producing BMP-2 in the posterior paraspinal muscles resulted in situ endochondral ossification adjacent to vertebrae.
Gene_expression (producing) of BMP-2 in vertebrae
1) Confidence 0.60 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2933711 Disease Relevance 0 Pain Relevance 0
Levels coded as fused by micro-CT after BMP-2 exposure also showed a significant decrease in intervertebral motion at 110° and 150° testing (3.1 ± 0.3° and 3.5 ± 0.4° respectively) compared to controls.
Gene_expression (exposure) of BMP-2
2) Confidence 0.58 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2933711 Disease Relevance 0 Pain Relevance 0
As an alternative method for inducing bone formation, PDLLA polymer pellets containing BMP-2 were implanted intramuscularly in quadriceps of C57BL6/J mice.
Gene_expression (containing) of BMP-2 in quadriceps
3) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.08 Pain Relevance 0
g recombinant human BMP-2 (Medronic Australasia) and 0 ?
Gene_expression (human) of BMP-2
4) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.14 Pain Relevance 0
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Gene_expression (Recombinant) of BMP-2
5) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Gene_expression (human) of BMP-2
6) Confidence 0.42 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Gene_expression (human) of rhBMP-2
7) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Recombinant human BMP-2 (rhBMP-2) (Medtronic Australasia, North Ryde, NSW, Australia) was solubilized in sterile water at stock concentrations of 100 ?
Gene_expression (Recombinant) of rhBMP-2
8) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0 Pain Relevance 0
Thus, the role of ALK-1 is dependant of type II receptor expression and ligand availability.
Gene_expression (expression) of type II receptor
9) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0
type II receptor fused with the Fc domain of a human IgG1.
Gene_expression (fused) of type II receptor
10) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.55 Pain Relevance 0.05
A significant association between loss of BMPR2 expression and tumor grade was found in bladder transitional cell carcinoma [54].
Gene_expression (expression) of BMPR2 in bladder associated with cancer and transitional cell carcinoma
11) Confidence 0.31 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.65 Pain Relevance 0
Toom et al. [18] found that the expression of BMP-2 and TGF are higher in ectopic bones and Chauvean et al. [19] reported strong over expression of osteocalcin mRNA, an event associated with upregulation of osteonectin and collagen type I synthesis.
Gene_expression (expression) of BMP-2
12) Confidence 0.28 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956094 Disease Relevance 0.20 Pain Relevance 0
BMP-2 and BMP-2 receptors are expressed in a variety normal and malignant cell types, including osteosarcoma.
Gene_expression (expressed) of BMP-2 associated with malignant neoplastic disease and osteogenic sarcomas
13) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.84 Pain Relevance 0
Multiple studies have questioned the impact of excess BMP-2 production in patients with osteosarcoma.
Gene_expression (production) of BMP-2 associated with osteogenic sarcomas
14) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.75 Pain Relevance 0
Tsuji et al (2006) evaluated the role of BMP-2 in fracture healing by creating transgenic mice lacking limb specific expression of BMP-2.
Gene_expression (expression) of BMP-2 in limb associated with targeted disruption and fracture healing
15) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.51 Pain Relevance 0
With a similar technique, Lieberman et al noted enhanced bone healing in hindlimbs of mice treated with helper-dependent adenoviral vector producing BMP-2 (Abe et al 2002).
Gene_expression (producing) of BMP-2 in hindlimbs
16) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.54 Pain Relevance 0
BMP-2 and BMP-2 receptors are expressed in a variety normal and malignant cell types, including osteosarcoma.
Gene_expression (expressed) of BMP-2 associated with malignant neoplastic disease and osteogenic sarcomas
17) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.84 Pain Relevance 0
2 KO embryos, although it should be kept in mind that despite their similar expression pattern at the NMJ, wit is a BMP type II receptor orthologue and gbb also represents a BMP orthologue rather than a TGF-?
Gene_expression (orthologue) of BMP type II receptor in embryos
18) Confidence 0.20 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.13 Pain Relevance 0.05
The mechanism of the osteogenic effect of Rhizoma Drynariae can be partially explained by the activation of BMP-2 gene expression through the HMG-CoA reductase inhibition effect of naringin.
Gene_expression (expression) of BMP-2 gene
19) Confidence 0.20 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.08 Pain Relevance 0
It is possible that orcinol glucoside also affects the redox reaction of the HMG-CoA transformation to mevalonate and triggers the BMP-2 gene expression.
Gene_expression (expression) of BMP-2 gene
20) Confidence 0.20 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.06 Pain Relevance 0

General Comments

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