INT81991

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ODF1) structural molecule activity (ODF1) plasma membrane (Bmpr2)
kinase activity (Bmpr2) cytoplasm (Bmpr2)
Anatomy Link Frequency
osteoblast 2
Bmpr2 (Mus musculus)
ODF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 94.88 High High
COX-2 inhibitor 3 88.88 High High
COX2 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteoporosis 18 99.60 Very High Very High Very High
INFLAMMATION 3 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since BMP-2 alone induced the expression of COX-2 and ODF genes in osteoblast-like cells, it appears to be one of the regulating factors of osteoclastogenesis.
BMP-2 Positive_regulation (induced) of Gene_expression (expression) of ODF in osteoblast associated with osteoporosis
1) Confidence 0.03 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10334922 Disease Relevance 0.57 Pain Relevance 0.13
It is noted that BMP-2 alone did cause an increase in the expression of both COX-2 and ODF genes.
BMP-2 Positive_regulation (cause) of Gene_expression (expression) of ODF
2) Confidence 0.03 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10334922 Disease Relevance 0.51 Pain Relevance 0.14
It is noted that BMP-2 alone did cause an increase in the expression of both COX-2 and ODF genes.
BMP-2 Positive_regulation (increase) of Gene_expression (expression) of ODF
3) Confidence 0.03 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10334922 Disease Relevance 0.51 Pain Relevance 0.14

General Comments

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