INT82003

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Context Info
Confidence 0.20
First Reported 1999
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
spinal cord 2
nerve 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.96 Very High Very High Very High
gABA 10 98.78 Very High Very High Very High
substance P 8 89.04 High High
antagonist 2 87.68 High High
agonist 5 83.80 Quite High
nociceptor 4 81.60 Quite High
Antinociceptive 2 73.76 Quite High
antinociception 1 70.56 Quite High
GABAergic 1 66.84 Quite High
intrathecal 1 59.28 Quite High
Disease Link Frequency Relevance Heat
Nociception 2 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results provide evidence for a presynaptic control of nociceptive primary afferent neurons by GABA(B) but not GABA(A) receptors in the superficial laminae of the spinal cord, limiting tachykinin release.
Negative_regulation (limiting) of Localization (release) of tachykinin in spinal cord associated with nociception, gaba and spinal cord
1) Confidence 0.20 Published 2001 Journal Neuroscience Section Abstract Doc Link 11274791 Disease Relevance 0.10 Pain Relevance 0.96
We deduce that endocytosis in the presence of monensin was stimulated by the release of tachykinins from intrinsic nerve endings, based on the following evidence: when endogenous release of tachykinin was blocked using a high magnesium/low calcium solution, or binding of tachykinins to the receptor was prevented using 10(-6) M SR140333, the intracellular receptor immunoreactivity remained at approximately 40%.
Negative_regulation (blocked) of Localization (release) of tachykinin in nerve
2) Confidence 0.11 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336084 Disease Relevance 0 Pain Relevance 0.27

General Comments

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