INT82005

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 14
Disease Relevance 0
Pain Relevance 9.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
neurons 4
hippocampus 4
NAc 2
brain 2
body 2
Ppp1r1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 45 100.00 Very High Very High Very High
Dopamine 38 100.00 Very High Very High Very High
cocaine 33 100.00 Very High Very High Very High
Kappa opioid receptor 15 99.48 Very High Very High Very High
Hippocampus 5 99.24 Very High Very High Very High
tetrodotoxin 3 99.08 Very High Very High Very High
Analgesic 10 98.98 Very High Very High Very High
MU agonist 10 98.88 Very High Very High Very High
Morphine 10 97.64 Very High Very High Very High
adenocard 22 97.44 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the striatum, DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) is highly expressed by virtually all projection medium-sized spiny neurons. cAMP-dependent phosphorylation of DARPP-32 is stimulated via activation of dopamine D1 receptors in striatonigral neurons, and via activation of adenosine A2A receptors in striatopallidal neurons.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of DARPP-32 in neurons associated with adenocard and dopamine
1) Confidence 0.69 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.40
A large body of evidence supports the key role of DARPP-32-dependent signalling in mediating the actions of multiple drugs of abuse, including cocaine, which, when acutely administered, increases the Thr(34) phosphorylation of DARPP-32 in the striatal and cortical areas.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of DARPP-32 in body associated with cocaine
2) Confidence 0.68 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.56
The results show that, at low concentrations (100 pm-1 nm), the mu-opioid agonist, Tyr-D-Ala-Gly-N-Me-Phe-glycinol (DAMGO), inhibits the increase in DARPP-32 phosphorylation induced by activation of D1, but not by activation of A2A receptors.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of DARPP-32 associated with mu agonist
3) Confidence 0.60 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.63
Conversely, the delta-receptor agonist, Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE), inhibits DARPP-32 phosphorylation induced by activation of A2A, but not by activation of D1 receptors.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of DARPP-32 associated with agonist
4) Confidence 0.50 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.72
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
Positive_regulation (cocaine-induced) of Phosphorylation (phosphorylation) of DARPP-32 in brain associated with analgesic, agonist, kappa opioid receptor and cocaine
5) Confidence 0.49 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.81
In the striatum, DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) is highly expressed by virtually all projection medium-sized spiny neurons. cAMP-dependent phosphorylation of DARPP-32 is stimulated via activation of dopamine D1 receptors in striatonigral neurons, and via activation of adenosine A2A receptors in striatopallidal neurons.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of DARPP-32 in neurons associated with adenocard and dopamine
6) Confidence 0.46 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.40
The results show that, at low concentrations (100 pm-1 nm), the mu-opioid agonist, Tyr-D-Ala-Gly-N-Me-Phe-glycinol (DAMGO), inhibits the increase in DARPP-32 phosphorylation induced by activation of D1, but not by activation of A2A receptors.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of DARPP-32 associated with mu agonist
7) Confidence 0.43 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.63
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of DARPP-32 in hippocampus associated with hippocampus and cocaine
8) Confidence 0.43 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Cocaine-sensitized rats showed increased phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein Mr 32 kDa (DARPP-32) at threonine-75 (Thr75) and decreased DARPP-32 phosphorylation at Thr34, in the caudate-putamen (CPu) and nucleus accumbens (NAc) 7 days after sensitization assessment.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of DARPP-32 in NAc associated with nucleus accumbens, dopamine and cocaine
9) Confidence 0.39 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 0.84
We show that, in striatal slices, the D2 receptor agonist, quinpirole, strongly inhibits the phosphorylation of DARPP-32 induced by either the D1 receptor agonist, SKF 81297, or the A2A receptor agonist, CGS 21680.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of DARPP-32 associated with agonist
10) Confidence 0.33 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.83
Tetrodotoxin abolished the effect of quinpirole on the D1 agonist-induced but not the A2A agonist-induced phosphorylation of DARPP-32.
Positive_regulation (agonist-induced) of Phosphorylation (phosphorylation) of DARPP-32 associated with tetrodotoxin and agonist
11) Confidence 0.24 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.84
Tetrodotoxin abolished the effect of quinpirole on the D1 agonist-induced but not the A2A agonist-induced phosphorylation of DARPP-32.
Neg (not) Positive_regulation (agonist-induced) of Phosphorylation (phosphorylation) of DARPP-32 associated with tetrodotoxin and agonist
12) Confidence 0.24 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.83
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of in prefrontal Phosphorylation (phosphorylation) of DARPP-32 in hippocampus associated with hippocampus and cocaine
13) Confidence 0.14 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68
Results showed that a single injection of cocaine induces a significant increase in DARPP-32 phosphorylation at Thr(34) in the hippocampus, caudate putamen and prefrontal cortex.
Positive_regulation (increase) of in caudate putamen Phosphorylation (phosphorylation) of DARPP-32 in hippocampus associated with hippocampus and cocaine
14) Confidence 0.14 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.68

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