INT82009

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.85
Pain Relevance 4.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
PC-12 2
NAc 2
projection neurons 2
brain 2
Ppp1r1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 9 100.00 Very High Very High Very High
agonist 18 99.82 Very High Very High Very High
Dopamine 17 99.72 Very High Very High Very High
Kappa opioid receptor 3 99.66 Very High Very High Very High
adenocard 10 99.28 Very High Very High Very High
Analgesic 2 99.16 Very High Very High Very High
projection neuron 7 98.48 Very High Very High Very High
Nucleus accumbens 3 98.24 Very High Very High Very High
Intracerebroventricular 2 98.08 Very High Very High Very High
GABAergic 2 95.00 High High
Disease Link Frequency Relevance Heat
Tics 10 98.18 Very High Very High Very High
Pheochromocytoma 2 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the delta-receptor agonist, Tyr-D-Pen-Gly-Phe-D-Pen (DPDPE), inhibits DARPP-32 phosphorylation induced by activation of A2A, but not by activation of D1 receptors.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of DARPP-32 associated with agonist
1) Confidence 0.58 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.72
Cocaine-sensitized rats showed increased phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein Mr 32 kDa (DARPP-32) at threonine-75 (Thr75) and decreased DARPP-32 phosphorylation at Thr34, in the caudate-putamen (CPu) and nucleus accumbens (NAc) 7 days after sensitization assessment.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of DARPP-32 in NAc associated with nucleus accumbens, dopamine and cocaine
2) Confidence 0.49 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15287884 Disease Relevance 0 Pain Relevance 0.97
The kappa-opioid receptor agonist U-69593 prevents cocaine-induced phosphorylation of DARPP-32 at Thr(34) in the rat brain.
Negative_regulation (prevents) of Phosphorylation (phosphorylation) of DARPP-32 in brain associated with analgesic, agonist, kappa opioid receptor and cocaine
3) Confidence 0.42 Published 2007 Journal Brain Res. Bull. Section Title Doc Link 17499634 Disease Relevance 0 Pain Relevance 0.81
FMRFamide also inhibited DARPP-32/Thr34 phosphorylation in the presence of forskolin.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of DARPP-32
4) Confidence 0.31 Published 2006 Journal Peptides Section Abstract Doc Link 16490283 Disease Relevance 0.41 Pain Relevance 0.40
We show that, in striatal slices, the D2 receptor agonist, quinpirole, strongly inhibits the phosphorylation of DARPP-32 induced by either the D1 receptor agonist, SKF 81297, or the A2A receptor agonist, CGS 21680.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of DARPP-32 associated with agonist
5) Confidence 0.28 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.83
Activation of dopamine D2 receptors decreases DARPP-32 phosphorylation in striatonigral and striatopallidal projection neurons via different mechanisms.
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of DARPP-32 in projection neurons associated with adenocard, dopamine and projection neuron
6) Confidence 0.28 Published 1999 Journal Neuroscience Section Title Doc Link 10336115 Disease Relevance 0 Pain Relevance 0.80
Similarly, PFR(Tic)amide, a 'super-agonist' of NPFF receptors, inhibited the production of cAMP and slightly decreased DARPP-32/Thr34 phosphorylation in PC-12/rNPFF1 cells.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of DARPP-32 in PC-12 associated with tics and agonist
7) Confidence 0.27 Published 2006 Journal Peptides Section Abstract Doc Link 16490283 Disease Relevance 0.43 Pain Relevance 0.42

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