INT82022

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Context Info
Confidence 0.08
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ngf) enzyme binding (Trib3) extracellular space (Ngf)
signal transduction (Ngf) extracellular region (Ngf) nucleolus (Trib3)
Trib3 (Rattus norvegicus)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 100.00 Very High Very High Very High
Lasting pain 1 96.56 Very High Very High Very High
Neuropathic pain 2 83.04 Quite High
IPN 2 79.92 Quite High
antagonist 2 75.00 Quite High
antiallodynic 1 75.00 Quite High
intrathecal 1 73.20 Quite High
Morphine 2 71.04 Quite High
Brush evoked pain 1 33.36 Quite Low
Potency 1 26.16 Quite Low
Disease Link Frequency Relevance Heat
Pain 3 96.56 Very High Very High Very High
Neuropathic Pain 4 83.04 Quite High
Inflammatory Pain 2 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA (IC50 5.88 +/- 1. 87 microM, 3.72 +/- 1.3 microM, respectively), as well as signal transduction and biological responses mediated by TrkA receptors.
kinase Binding (binding) of NGF associated with nerve growth factor
1) Confidence 0.08 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336516 Disease Relevance 0.31 Pain Relevance 0.68

General Comments

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