INT82023

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.48
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ntrk1, Ngf) cell differentiation (Ntrk1) endosome (Ntrk1)
cytoplasm (Ntrk1) extracellular space (Ngf) signal transduction (Ngf)
Anatomy Link Frequency
nerve 1
neurons 1
Ntrk1 (Rattus norvegicus)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 35 100.00 Very High Very High Very High
Trk A 9 100.00 Very High Very High Very High
Hsan 4 98.72 Very High Very High Very High
Lasting pain 4 96.56 Very High Very High Very High
Pain 15 92.08 High High
Analgesic 6 89.12 High High
Osteoarthritis 1 86.72 High High
Neuropathic pain 6 85.28 High High
Pain threshold 1 83.04 Quite High
Hyperalgesia 1 82.92 Quite High
Disease Link Frequency Relevance Heat
Hereditary Sensory And Autonomic Neuropathies 4 98.72 Very High Very High Very High
Injury 7 97.00 Very High Very High Very High
Pain 16 96.56 Very High Very High Very High
Nociception 1 92.00 High High
Cystitis 1 87.52 High High
Osteoarthritis 1 86.72 High High
Neuropathic Pain 10 85.28 High High
Burns 1 84.16 Quite High
Hyperalgesia 1 82.92 Quite High
Inflammatory Pain 4 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA (IC50 5.88 +/- 1. 87 microM, 3.72 +/- 1.3 microM, respectively), as well as signal transduction and biological responses mediated by TrkA receptors.
Trk Binding (binding) of NGF associated with nerve growth factor
1) Confidence 0.53 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336516 Disease Relevance 0.32 Pain Relevance 0.69
NGF interacts with high-affinity binding sites, termed trk A receptors, located on the cell membranes of responsive neurons.
trk A Binding (interacts) of NGF in neurons associated with nerve growth factor and trk a
2) Confidence 0.40 Published 2000 Journal J Endod Section Abstract Doc Link 11194379 Disease Relevance 0.60 Pain Relevance 0.51
We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA (IC50 5.88 +/- 1. 87 microM, 3.72 +/- 1.3 microM, respectively), as well as signal transduction and biological responses mediated by TrkA receptors.
Trk Binding (binding) of NGF associated with nerve growth factor
3) Confidence 0.34 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336516 Disease Relevance 0.31 Pain Relevance 0.68
Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene which encodes the receptor for nerve growth factor (NGF).
neurotrophic tyrosine receptor kinase 1 Binding (receptor) of NGF in nerve associated with nerve growth factor and hsan
4) Confidence 0.06 Published 2005 Journal Neuropediatrics Section Abstract Doc Link 16138253 Disease Relevance 0.98 Pain Relevance 0.58
Current options being explored include the development of humanized monoclonal antibodies to NGF or its tyrosine kinase receptor TrkA (also known as neurotrophic tyrosine kinase receptor, type 1 [NTRK1]), and the sequestration of NGF using TrkA domain 5 (TrkAd5), a soluble receptor protein that binds NGF with picomolar affinity.
NTRK1 Binding (binds) of NGF associated with nerve growth factor
5) Confidence 0.04 Published 2008 Journal BioDrugs Section Abstract Doc Link 18998753 Disease Relevance 1.27 Pain Relevance 1.47

General Comments

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