INT82024

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr, Ngf) cell differentiation (Ngfr) nuclear envelope (Ngfr)
aging (Ngf) Golgi apparatus (Ngfr) cytoplasm (Ngfr)
Ngfr (Rattus norvegicus)
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 100.00 Very High Very High Very High
Lasting pain 1 96.56 Very High Very High Very High
Spinal cord 66 87.36 High High
Neuropathic pain 2 84.64 Quite High
IPN 2 81.52 Quite High
Central nervous system 10 76.84 Quite High
Demyelination 1 75.12 Quite High
antagonist 2 75.00 Quite High
antiallodynic 1 75.00 Quite High
intrathecal 1 74.80 Quite High
Disease Link Frequency Relevance Heat
Pain 3 96.56 Very High Very High Very High
Injury 5 89.96 High High
Spinal Cord Injury 33 87.36 High High
Neuropathic Pain 4 84.64 Quite High
Inflammatory Pain 2 81.52 Quite High
Apoptosis 28 80.08 Quite High
Death 10 76.16 Quite High
Demyelinating Disease 1 75.12 Quite High
Necrosis 2 70.56 Quite High
Cancer 2 70.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have identified a novel nonpeptidic molecule, ALE-0540, that inhibits the binding of NGF to tyrosine kinase (Trk) A or both p75 and TrkA (IC50 5.88 +/- 1. 87 microM, 3.72 +/- 1.3 microM, respectively), as well as signal transduction and biological responses mediated by TrkA receptors.
p75 Binding (binding) of NGF associated with nerve growth factor
1) Confidence 0.33 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336516 Disease Relevance 0.32 Pain Relevance 0.69
In addition to its function as a low-affinity receptor for NGF, p75NTR forms a receptor complex together with Nogo-66 receptor and LINGO-1, transmitting the signal from myelin-derived inhibitors [28-30].
p75NTR Binding (receptor) of NGF
2) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 1.17 Pain Relevance 0.36

General Comments

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