INT82035

Context Info Confidence 0.13 First Reported 1999 Last Reported 2009 Negated 0 Speculated 0 Reported most in Title Documents 3 Total Number 3 Disease Relevance 0 Pain Relevance 3.16

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency projection neurons 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 26 100.00 agonist 4 100.00 antagonist 1 100.00 narcan 1 100.00 Enkephalin 2 99.84 withdrawal 2 99.72 projection neuron 1 98.52 Morphine 15 98.24 Antinociceptive 7 97.88 tolerance 9 97.24

Disease Link Frequency Relevance Heat Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.

Negative_regulation (Disruption) of Phosphorylation (phosphorylation) of delta-opioid receptor associated with tolerance, opioid receptor, antinociceptive and morphine

1) Confidence 0.13 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.53

Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons.

Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of delta-opioid receptor in projection neurons associated with agonist, enkephalin, projection neuron and opioid receptor

2) Confidence 0.10 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.70

Withdrawal caused by an opioid receptor antagonist - naloxone - attenuated phosphorylation of ERK1/2.

Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of opioid receptor associated with antagonist, narcan, opioid receptor and withdrawal

3) Confidence 0.01 Published 2008 Journal FEBS J. Section Abstract Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.93

General Comments

This test has worked.