INT82035

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Context Info
Confidence 0.13
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
projection neurons 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 26 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
narcan 1 100.00 Very High Very High Very High
Enkephalin 2 99.84 Very High Very High Very High
withdrawal 2 99.72 Very High Very High Very High
projection neuron 1 98.52 Very High Very High Very High
Morphine 15 98.24 Very High Very High Very High
Antinociceptive 7 97.88 Very High Very High Very High
tolerance 9 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance.
Negative_regulation (Disruption) of Phosphorylation (phosphorylation) of delta-opioid receptor associated with tolerance, opioid receptor, antinociceptive and morphine
1) Confidence 0.13 Published 2009 Journal J. Neurosci. Section Title Doc Link 19295160 Disease Relevance 0 Pain Relevance 1.53
Mu- and delta-opioid receptor agonists inhibit DARPP-32 phosphorylation in distinct populations of striatal projection neurons.
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of delta-opioid receptor in projection neurons associated with agonist, enkephalin, projection neuron and opioid receptor
2) Confidence 0.10 Published 1999 Journal Eur. J. Neurosci. Section Title Doc Link 10336688 Disease Relevance 0 Pain Relevance 0.70
Withdrawal caused by an opioid receptor antagonist - naloxone - attenuated phosphorylation of ERK1/2.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of opioid receptor associated with antagonist, narcan, opioid receptor and withdrawal
3) Confidence 0.01 Published 2008 Journal FEBS J. Section Abstract Doc Link 18616461 Disease Relevance 0 Pain Relevance 0.93

General Comments

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