INT82046

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.63
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ODC1) small molecule metabolic process (ODC1) lyase activity (ODC1)
cellular nitrogen compound metabolic process (ODC1) cellular_component (ODC1)
Anatomy Link Frequency
colon 1
ODC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 6 94.68 High High
cINOD 9 71.44 Quite High
qutenza 2 63.68 Quite High
intrathecal 9 45.24 Quite Low
COX-2 inhibitor 2 25.00 Low Low
cva 3 22.96 Low Low
COX2 1 10.00 Low Low
Central nervous system 9 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 125 99.84 Very High Very High Very High
Necrosis 1 99.60 Very High Very High Very High
Colorectal Cancer 94 97.60 Very High Very High Very High
Stress 1 96.84 Very High Very High Very High
INFLAMMATION 9 94.68 High High
Colon Cancer 14 91.40 High High
Apoptosis 4 84.00 Quite High
Leukemia 1 83.84 Quite High
Death 1 77.44 Quite High
Infection 31 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ODC activity was expressed as pmol CO2/h/mg of protein.


Gene_expression (expressed) of ODC
1) Confidence 0.59 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0 Pain Relevance 0
expression, as well as ODC and SSAT mRNA levels were significantly higher (p < 0.05; Mann Whitney test) in colorectal carcinoma samples expressing K-ras mutation as compared to non mutated K-ras samples.
Gene_expression (expression) of ODC associated with colorectal cancer
2) Confidence 0.53 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.30 Pain Relevance 0
, SSAT and ODC gene expression as well as polyamine levels and ODC and SSAT activities, in neoplastic samples and in surrounding uninvolved mucosa.
Gene_expression (expression) of ODC gene
3) Confidence 0.53 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.70 Pain Relevance 0
, ODC and SSAT gene expression
Gene_expression (expression) of ODC
4) Confidence 0.53 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1543652 Disease Relevance 0.55 Pain Relevance 0
Activities of polyamine-metabolising enzymes, polyamine content (HPLC) and ODC and c-myc protein expression (Western blot) were measured in colon cancer cells treated with indomethacin during logarithmic phase of proliferation.
Gene_expression (expression) of ODC in colon
5) Confidence 0.52 Published 2001 Journal Eur. J. Clin. Invest. Section Body Doc Link 11737227 Disease Relevance 0.09 Pain Relevance 0
Examples are provided by the expression of ornithine decarboxylase and the activation of eicosanoid formation from arachidonic acid.
Gene_expression (expression) of ornithine decarboxylase
6) Confidence 0.45 Published 1999 Journal Recent Results Cancer Res. Section Abstract Doc Link 10337718 Disease Relevance 0.80 Pain Relevance 0.07
These diarylheptanoids suppress phorbol ester-induced activation of ornithine decarboxylase and production of tumor necrosis factor-alpha or interleukin-1alpha and their mRNA expression.
Gene_expression (production) of ornithine decarboxylase associated with necrosis and cancer
7) Confidence 0.12 Published 1999 Journal Mutat. Res. Section Abstract Doc Link 10518003 Disease Relevance 0.98 Pain Relevance 0.14
The isolates were positive for catalase, clumping factor, pyrrolidonyl arylamidase, and ornithine decarboxylase.
Gene_expression (positive) of ornithine decarboxylase
8) Confidence 0.00 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2529306 Disease Relevance 0.20 Pain Relevance 0

General Comments

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