INT82048

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Context Info
Confidence 0.49
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 2.39
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Neurod1) nucleocytoplasmic transport (Neurod1) nucleus (Neurod1)
DNA binding (Neurod1) transcription factor binding (Neurod1) cytoplasm (Neurod1)
Anatomy Link Frequency
GFAP 3
liver 2
Neurod1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 98.90 Very High Very High Very High
Nicotine 7 98.64 Very High Very High Very High
Lasting pain 4 97.44 Very High Very High Very High
Paracetamol 7 95.96 Very High Very High Very High
Inflammatory response 3 95.16 Very High Very High Very High
antagonist 1 95.00 High High
tetrodotoxin 6 92.64 High High
Catecholamine 1 90.48 High High
Inflammation 2 87.52 High High
qutenza 2 85.04 High High
Disease Link Frequency Relevance Heat
Liver Disease 1 97.80 Very High Very High Very High
Pain 5 97.44 Very High Very High Very High
Disease 3 96.76 Very High Very High Very High
Overdose 8 96.32 Very High Very High Very High
INFLAMMATION 5 94.80 High High
Targeted Disruption 18 92.16 High High
Injury 6 91.12 High High
Neurodegenerative Disease 47 90.04 High High
Nociception 2 84.72 Quite High
Hepatitis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, strategies reducing the activity of peptidergic sensory nerve fibres or stimulating beta2-adrenoreceptors, may be of benefit in immune-mediated liver disease.
Positive_regulation (stimulating) of beta2 in liver associated with liver disease
1) Confidence 0.49 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10337911 Disease Relevance 0.60 Pain Relevance 0.18
Because of the critical importance of beta2 integrins for neutrophil cytotoxicity, these results suggest that neutrophils do not contribute to the initiation or progression of AAP-induced liver.
Positive_regulation (importance) of beta2 in liver
2) Confidence 0.49 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10774834 Disease Relevance 0.79 Pain Relevance 0.67
In contrast, specific bHLH genes, including those encoding NeuroD1, NeuroD6, Msc, and Nhlh2, were increased, and, perhaps consistent with this, the inhibitory bHLH factor Id1, which can act to oppose the action of neurogenic bHLH genes, was decreased.
Positive_regulation (increased) of NeuroD1
3) Confidence 0.47 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.18 Pain Relevance 0
Conversely, the alpha7-subunit-selective agonist choline (10 mM) caused a methyllycaconitine-sensitive increase in intracellular Ca2+ level both in wild-type and beta2-/- mutant mice.
Positive_regulation (increase) of beta2 associated with agonist
4) Confidence 0.45 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10947823 Disease Relevance 0 Pain Relevance 0.76
Furthermore, the number of NeuroD (a neurogenic basic helix-loop-helix factor)-positive cells, in the DG was clearly increased by EE.
Positive_regulation (increased) of NeuroD
5) Confidence 0.44 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18565655 Disease Relevance 0.82 Pain Relevance 0.43
Differentiating cultures up-regulated mRNA for NeuroD1, a key transcription factor in the neuronal lineage (Fig. 5d) and also expressed mRNA for GFAP.
Positive_regulation (regulated) of NeuroD1 in GFAP
6) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
Differentiating cultures up-regulated mRNA for NeuroD1, a key transcription factor in the neuronal lineage (Fig. 5d) and also expressed mRNA for GFAP.
Positive_regulation (up) of NeuroD1 in GFAP
7) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
Differentiating cultures up-regulated mRNA for NeuroD1, a key transcription factor in the neuronal lineage (Fig. 5d) and also expressed mRNA for GFAP.
Positive_regulation (-) of NeuroD1 in GFAP
8) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0 Pain Relevance 0
In situ mRNA hybridization was also performed to determine if altered mRNA transcription mediated the interdependence of alpha4 and beta2 subunit expression. alpha4-Null mutation did not affect beta2 mRNA expression, nor did beta2 genotype affect alpha4 mRNA expression.
Positive_regulation (interdependence) of beta2
9) Confidence 0.16 Published 2006 Journal J. Comp. Neurol. Section Abstract Doc Link 17072836 Disease Relevance 0 Pain Relevance 0.10

General Comments

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