INT8205

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Context Info
Confidence 0.59
First Reported 1985
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 77
Total Number 78
Disease Relevance 26.43
Pain Relevance 25.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 17
auricles 3
kidney 2
blood vessels 2
heart 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 45 100.00 Very High Very High Very High
antagonist 33 100.00 Very High Very High Very High
anesthesia 16 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
GABAergic 2 99.98 Very High Very High Very High
agonist 24 99.96 Very High Very High Very High
antinociception 2 99.92 Very High Very High Very High
Dismenorea 26 99.80 Very High Very High Very High
Clonidine 69 99.78 Very High Very High Very High
tetrodotoxin 12 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 195 100.00 Very High Very High Very High
Body Weight 56 100.00 Very High Very High Very High
Reprotox - General 1 35 99.80 Very High Very High Very High
Hypertension 21 99.60 Very High Very High Very High
Porphyria 12 99.52 Very High Very High Very High
Congenital Anomalies 15 99.36 Very High Very High Very High
Obesity 2 99.32 Very High Very High Very High
Pressure And Volume Under Development 16 99.10 Very High Very High Very High
Spasticity 3 98.98 Very High Very High Very High
Stress 16 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that ANF probably does not contribute to the depressor effect of centrally administered clonidine, while in SHRsp the decrease of plasma ANF might be a blood pressure-dependent compensatory response.
Negative_regulation (decrease) of ANF in blood associated with clonidine
1) Confidence 0.59 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1836674 Disease Relevance 0.49 Pain Relevance 0.60
Compared with the control rats, we found for the first time a significant decrease of ANF in plasma and a marked increase of ANF in atria in morphine tolerant rats.
Negative_regulation (decrease) of ANF in plasma associated with morphine
2) Confidence 0.59 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2533995 Disease Relevance 0.07 Pain Relevance 0.38
Abolishing contraction with 10 microM tetrodotoxin significantly reduced ANP accumulated in 2 h.
Negative_regulation (reduced) of ANP associated with tetrodotoxin
3) Confidence 0.59 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Moreover, yohimbine in highest doses (50 micrograms) decreased the basal plasma IR-ANF from 34.0 +/- 7.0 pg/ml (means +/- S.E.M.) to 6.8 +/- 3.6 pg/ml.
Negative_regulation (decreased) of ANF in plasma
4) Confidence 0.59 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.14 Pain Relevance 0.52
Naloxone also significantly decreased the basal IR-ANF level (P less than 0.05) to 49.0 +/- 5.3 pg/ml.
Negative_regulation (decreased) of ANF associated with narcan
5) Confidence 0.59 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2949987 Disease Relevance 0.17 Pain Relevance 0.74
Moreover, the effect of clonidine on plasma ANP was partially blocked by pretreatment with naloxone (5 micrograms/min).
Negative_regulation (blocked) of ANP in plasma associated with narcan and clonidine
6) Confidence 0.59 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2525782 Disease Relevance 0.15 Pain Relevance 1.03
This treatment inhibited ANF released through in vivo blood volume expansion and through balloon inflation in the right atrium of in vitro isolated perfused hearts.
Negative_regulation (inhibited) of ANF in right atrium
7) Confidence 0.59 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1703316 Disease Relevance 0.16 Pain Relevance 0.39
To investigate the impact of changes in the level of the endogenous atrial natriuretic factor (ANF) on pituitary-adrenocortical activity, the secretion of corticotropin (ACTH) and corticosterone was studied under the conditions of enhanced and decreased circulating ANF levels in rats.
Negative_regulation (decreased) of ANF in pituitary associated with natriuresis
8) Confidence 0.59 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.10 Pain Relevance 0.06
Water deprivation for 48 h resulted in decreased ANF levels and increased corticosterone concentrations.
Negative_regulation (decreased) of ANF
9) Confidence 0.59 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.08 Pain Relevance 0.09
When intravenous glucose infusion is omitted, the above-described inhibition of ANP does not take place.
Negative_regulation (inhibition) of ANP
10) Confidence 0.58 Published 1999 Journal Hypertension Section Abstract Doc Link 10523368 Disease Relevance 0.38 Pain Relevance 0.17
In all 3 cases, pretreatment with HOE-140 (2.5 microg IV) fully prevented the inhibition of ANP excretory action, ruling out osmotic effects as the cause of reduced diuresis.
Negative_regulation (inhibition) of ANP in excretory associated with diuresis
11) Confidence 0.58 Published 1999 Journal Hypertension Section Abstract Doc Link 10523368 Disease Relevance 0.45 Pain Relevance 0.13
ANP effect was inhibited by the potassium channel blockers, but not by L-NAME, suggesting that potassium channel opening is a consequence of an increased cGMP content.
Negative_regulation (inhibited) of ANP associated with potassium channel
12) Confidence 0.53 Published 2003 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 13679232 Disease Relevance 0.07 Pain Relevance 0.93
Muscimol injection into the solitary tract nucleus, commissural part, reduced inhibition of PND and RTN by PBG (73%), blocked activation of PND and RTN by CB stimulation (cyanide) but had no effect on inhibition of PND and RTN by lung inflation.
Negative_regulation (inhibition) of PND in RTN associated with porphyria
13) Confidence 0.51 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17928558 Disease Relevance 0.50 Pain Relevance 0.29
Atrial natriuretic peptide (ANP) binding levels were decreased in smooth muscle of all blood vessels after 7 days of hypoxia, but endothelin-1 (ET-1) and vasoactive intestinal peptide (VIP) binding was unchanged.
Negative_regulation (decreased) of ANP in blood vessels associated with natriuresis and hypoxia
14) Confidence 0.50 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666097 Disease Relevance 0.86 Pain Relevance 0.60
Atrial natriuretic peptide (ANP) binding levels were decreased in smooth muscle of all blood vessels after 7 days of hypoxia, but endothelin-1 (ET-1) and vasoactive intestinal peptide (VIP) binding was unchanged.
Negative_regulation (decreased) of Atrial natriuretic peptide in blood vessels associated with natriuresis and hypoxia
15) Confidence 0.50 Published 1995 Journal Eur. Respir. J. Section Abstract Doc Link 8666097 Disease Relevance 0.87 Pain Relevance 0.60
These changes were associated with a decrease in plasma ANP, BNP and ET-1 concentrations.
Negative_regulation (decrease) of ANP in plasma
16) Confidence 0.44 Published 2001 Journal Cardiovasc. Res. Section Body Doc Link 11476752 Disease Relevance 0.06 Pain Relevance 0
At the same time, plasma IR-ANF decreased from 113.3 +/- 32.2 to 30.3 +/- 11.4 after yohimbine and to 24.6 +/- 12.1 pg/ml after naloxone treatment (P less than 0.05).
Negative_regulation (decreased) of ANF in plasma associated with narcan
17) Confidence 0.43 Published 1988 Journal Endocrinology Section Abstract Doc Link 2841088 Disease Relevance 0.29 Pain Relevance 0.99
We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles.
Negative_regulation (deprivation) of ANP in auricles associated with natriuresis and morphine
18) Confidence 0.43 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.32
We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles.
Negative_regulation (deprivation) of atrial natriuretic peptide in auricles associated with natriuresis and morphine
19) Confidence 0.43 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.32
The secretagogue action of i.c.v. administered ANP was totally abolished by truncal vagotomy.
Negative_regulation (abolished) of ANP
20) Confidence 0.43 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2959490 Disease Relevance 0.17 Pain Relevance 0.04

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