INT82051

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.81
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE3)
Anatomy Link Frequency
eosinophil 4
blood 1
sputum 1
RNASE3 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 80 91.64 High High
Pain 2 84.88 Quite High
Inflammatory mediators 6 83.20 Quite High
dexamethasone 5 81.36 Quite High
pain pelvic 1 68.44 Quite High
Inflammation 307 55.80 Quite High
cytokine 315 48.00 Quite Low
agonist 67 21.44 Low Low
antagonist 106 5.00 Very Low Very Low Very Low
Inflammatory response 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 2 8 100.00 Very High Very High Very High
Asthma 1001 98.38 Very High Very High Very High
Cough 6 94.76 High High
Stress 14 93.40 High High
Death 7 93.08 High High
Threatened Abortion 4 92.36 High High
Eosinophilia 112 88.24 High High
Adhesions 24 85.36 High High
Hypersensitivity 75 85.28 High High
Pain 1 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At this level, a test for the condition "absence of ECP" had a specificity of 99%, and only two of 212 ECPs in our group would test false-positive with an HCG value over 40K.
Negative_regulation (absence) of ECP associated with reprotox - general 2
1) Confidence 0.32 Published 1999 Journal J Emerg Med Section Abstract Doc Link 10338231 Disease Relevance 1.09 Pain Relevance 0.15
After short term treatment with glucocorticoids a significant decrease in the levels of serum eosinophil cationic protein (ECP) and serum eosinophil peroxidase was observed [43].
Negative_regulation (decrease) of ECP in eosinophil
2) Confidence 0.05 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.47 Pain Relevance 0.09
They showed improved pulmonary functions, reduced asthma symptoms and rescue medication use, increased time to severe exacerbations, and reduced peripheral blood eosinophil and serum eosinophil cationic protein levels.
Negative_regulation (reduced) of eosinophil cationic protein in eosinophil associated with asthma
3) Confidence 0.05 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.86 Pain Relevance 0
After short term treatment with glucocorticoids a significant decrease in the levels of serum eosinophil cationic protein (ECP) and serum eosinophil peroxidase was observed [43].
Negative_regulation (decrease) of cationic protein in eosinophil
4) Confidence 0.05 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 0.46 Pain Relevance 0.09
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of eosinophil cationic protein in sputum associated with asthma and cough
5) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.07
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of eosinophil cationic protein in blood associated with asthma and cough
6) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.07
In other small clinical trials, suplatast decreased blood and sputum eosinophils, blood and sputum eosinophil cationic protein levels, sputum mast cell tryptase levels, exhaled nitric oxide and airway responsiveness in patients with mild-moderate asthma or cough-variant asthma without causing significant side-effects [8].


Negative_regulation (decreased) of eosinophil cationic protein in eosinophils associated with asthma and cough
7) Confidence 0.01 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.21 Pain Relevance 0.07
For example, genetic removal of the RNaseIII Dicer in zebrafish and mice has shown the vital roles of miRNAs that are essential in many cellular processes such as in the development of a species.
Negative_regulation (removal) of RNaseIII
8) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.30 Pain Relevance 0

General Comments

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