INT82054

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 56
Total Number 59
Disease Relevance 17.45
Pain Relevance 37.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
dorsal horn 7
hippocampus 5
descending colon 4
spinal 3
neurons 3
Grin2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 726 100.00 Very High Very High Very High
antagonist 238 100.00 Very High Very High Very High
Dorsal horn 62 100.00 Very High Very High Very High
Nucleus accumbens 48 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 4 100.00 Very High Very High Very High
antinociception 14 99.96 Very High Very High Very High
Inflammation 125 99.90 Very High Very High Very High
Thermal hyperalgesia 54 99.84 Very High Very High Very High
qutenza 12 99.84 Very High Very High Very High
tolerance 76 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 102 99.90 Very High Very High Very High
Hyperalgesia 118 99.84 Very High Very High Very High
Depression 481 99.80 Very High Very High Very High
Brain Hemorrhage 120 99.24 Very High Very High Very High
Li-fraumeni Syndrome 44 99.12 Very High Very High Very High
Pain 123 98.48 Very High Very High Very High
Injury 87 98.28 Very High Very High Very High
Diabetes Mellitus 105 97.84 Very High Very High Very High
Stress 32 96.84 Very High Very High Very High
Neuropathic Pain 101 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parallel with this, protein levels of the NMDA receptor 2B subunit (NR2B) were elevated in the nucleus accumbens (NAc) and the hippocampus, but not the prefrontal cortex, of reinstated rats.
Positive_regulation (elevated) of NR2B in hippocampus associated with nucleus accumbens, nmda receptor and hippocampus
1) Confidence 0.70 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17014848 Disease Relevance 0.17 Pain Relevance 0.95
Parallel with this, protein levels of the NMDA receptor 2B subunit (NR2B) were elevated in the nucleus accumbens (NAc) and the hippocampus, but not the prefrontal cortex, of reinstated rats.
Positive_regulation (elevated) of NMDA receptor 2B subunit in hippocampus associated with nucleus accumbens, nmda receptor and hippocampus
2) Confidence 0.70 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17014848 Disease Relevance 0.17 Pain Relevance 0.95
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Positive_regulation (increase) of NR2B in hippocampus associated with nucleus accumbens, hippocampus and cocaine
3) Confidence 0.67 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.34
However, the postsynaptic AMPA and NMDA receptor subunits, GluR1, NR1 and NR2B, were increased.
Positive_regulation (increased) of NR2B associated with nmda receptor
4) Confidence 0.63 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622219 Disease Relevance 0.08 Pain Relevance 0.85
Here, we show that in rats with Freund's adjuvant-induced inflammation, the increased dorsal horn NR2B tyr-P is blocked by group I metabotropic glutamate receptor (mGluR) antagonists [7-(hydroxyimino)cyclopropa[b] chromen-1a-carboxylate ethyl ester (CPCCOEt) and 2-methyl-6-(phenylethynyl)-pyridine (MPEP), by the Src inhibitor CGP 77675, but not by the MAP kinase inhibitor 2'-amino-3'-methoxyflavone.
Positive_regulation (increased) of NR2B in dorsal horn associated with inflammation, antagonist, glutamate receptor and dorsal horn
5) Confidence 0.59 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15483135 Disease Relevance 0.44 Pain Relevance 0.85
Moreover, compared with the control group, both the increase in pNR2B and the cross-organ reflex sensitization were attenuated in the si-RNA of NR2B rats.
Positive_regulation (increase) of pNR2B
6) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.27 Pain Relevance 0.60
Chronic compression of the dorsal root ganglia induced time-dependent upregulation of nNOS and NR2B subunits of N-methyl-D-aspartate receptor within the spinal cord dorsal horn ipsilateral to CCD.
Positive_regulation (upregulation) of NR2B in dorsal root ganglia associated with nmda receptor, dorsal horn and spinal cord
7) Confidence 0.56 Published 2007 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 18000292 Disease Relevance 0.34 Pain Relevance 0.87
This suggests that activation of dorsal horn NR2B-containing NMDA receptors may be involved in use-dependent sensitization at the spinal level.


Positive_regulation (activation) of NR2B-containing in dorsal horn
8) Confidence 0.52 Published 2008 Journal Acta Physiol (Oxf) Section Body Doc Link 17970830 Disease Relevance 0.05 Pain Relevance 0
Our results indicate that increased NR2B in the penumbra after 24 h of focal cerebral ischemia may be comprised of combinations of NR2B subunit, along with the NR1 subunit (Monyer et al., 1992).
Positive_regulation (increased) of NR2B associated with brain hemorrhage and ischemia
9) Confidence 0.50 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.36 Pain Relevance 0.25
NR2B specific IgG in CSF in NR2B group could not be detected on day 1 before spinal dissection; but could be detected on day 7 after surgery.
Neg (not) Positive_regulation (detected) of NR2B in spinal
10) Confidence 0.50 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0.11 Pain Relevance 0
MDMA increased mRNA expression levels of glutamatergic NMDA receptor subunits NR1, NR2A and NR2B in the forebrain cortex, NR2A and 2B in the CPU, and NR1 and NR2A (lower dose) in the hypothalamus.
Positive_regulation (increased) of NR2B in forebrain associated with nmda receptor
11) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0.29
Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.
Positive_regulation (induce) of NR2B in dorsal horn associated with antinociception, antagonist and dorsal horn
12) Confidence 0.49 Published 1999 Journal Neuropharmacology Section Title Doc Link 10340299 Disease Relevance 0.07 Pain Relevance 0.80
Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals.
Positive_regulation (increase) of NR2B in hippocampus associated with nucleus accumbens, hippocampus and cocaine
13) Confidence 0.48 Published 2002 Journal Neuroscience Section Abstract Doc Link 11801363 Disease Relevance 0 Pain Relevance 1.35
This result indicates that NR2B-NMDARs are not required for the L-LTP.


Neg (not) Positive_regulation (required) of NR2B-NMDARs associated with long-term potentiation
14) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.31
Considering that the importance of NR2B-NMDARs for LTP induction is protocol-dependent, we attempted to know whether the role of NR2B-NMDARs in memory acquisition is also dependent on training paradigms.
Positive_regulation (importance) of NR2B-NMDARs associated with long-term potentiation
15) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.58 Pain Relevance 0.08
However, some other studies have reported that NR2B-NMDARs are not required for synaptic potentiation or LTP [9,10].
Neg (not) Positive_regulation (required) of NR2B-NMDARs associated with long-term potentiation
16) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0.32 Pain Relevance 0.42
This result indicates that NR2B-NMDARs are not required for LTP induced by the pairing protocol in the CA1 region, consistent with the previous report by Liu et al. [9]

LTP induced by high-frequency stimulation

Neg (not) Positive_regulation (required) of NR2B-NMDARs associated with long-term potentiation
17) Confidence 0.45 Published 2008 Journal Mol Brain Section Body Doc Link PMC2570668 Disease Relevance 0 Pain Relevance 0.42
According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A, and NR2B, induced by diverse types of reinforcers, we chose NR2B subunit as the target of research.
Positive_regulation (induced) of NR2B associated with nmda receptor
18) Confidence 0.45 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16631172 Disease Relevance 0.16 Pain Relevance 0.66
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of tNR2B in descending colon associated with action potential and spinal cord
19) Confidence 0.44 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.47
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Positive_regulation (increased) of NR2B in descending colon associated with action potential and spinal cord
20) Confidence 0.44 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.46

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