INT82055

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 176
Total Number 179
Disease Relevance 60.20
Pain Relevance 58.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
brain 10
hippocampus 7
neurons 6
NAc 5
spinal cord 4
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 483 100.00 Very High Very High Very High
bDMF 407 100.00 Very High Very High Very High
Kinase C 110 100.00 Very High Very High Very High
Central nervous system 80 100.00 Very High Very High Very High
antidepressant 2885 99.98 Very High Very High Very High
fluoxetine 579 99.98 Very High Very High Very High
Neurotransmitter 241 99.98 Very High Very High Very High
antagonist 448 99.96 Very High Very High Very High
Neuropeptide 47 99.90 Very High Very High Very High
long-term potentiation 907 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 134 100.00 Very High Very High Very High
Stress 1682 99.98 Very High Very High Very High
Apoptosis 198 99.98 Very High Very High Very High
Neurodegenerative Disease 437 99.90 Very High Very High Very High
Anxiety Disorder 1140 99.84 Very High Very High Very High
INFLAMMATION 218 99.82 Very High Very High Very High
Convulsion 67 99.74 Very High Very High Very High
Insulin Resistance 46 99.74 Very High Very High Very High
Schizophrenia 19 99.72 Very High Very High Very High
Nervous System Injury 26 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it was unknown whether the selective inhibition of serotonin reuptake is sufficient for inhibition of stress-induced CREB activation, as it is for the clinical antidepressant effect.
Spec (whether) Positive_regulation (activation) of CREB associated with stress, antidepressant and serotonin
1) Confidence 0.70 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.58 Pain Relevance 0.70
These results further emphasize the role of CREB in stress-induced gene expression and suggest furthermore that inhibition of stress-induced CREB activity may be a common mechanism of action of SSRIs underlying their antidepressive effect.
Positive_regulation (induced) of CREB associated with stress and ssri
2) Confidence 0.70 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.62 Pain Relevance 0.53
This increased excitability was mediated by direct activation of opioid receptors and up-regulation of the cAMP pathway and accompanied by increased cAMP response-element binding protein (CREB) activity.
Positive_regulation (increased) of CREB associated with opioid receptor
3) Confidence 0.69 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20837544 Disease Relevance 0.07 Pain Relevance 1.19
CBP has been considered for long time as the only interacting partner of CREB as it conveys activation of CREB to the basal transcription machinery [9].
Positive_regulation (activation) of CREB
4) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.26 Pain Relevance 0
Finally, treatment with imipramine of the stressed subordinate mice in the sensory contact model resulted in a reversal of the stress-induced increase in CREB activity to control levels, and also CREB phosphorylation was normalized.
Positive_regulation (increase) of CREB associated with stress
5) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.68 Pain Relevance 0.33
Effect of imipramine treatment on the stress-induced increase in CREB-phosphorylation
Positive_regulation (increase) of CREB associated with stress
6) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.65 Pain Relevance 0.08
Interestingly, as reviewed by Tardito et al.[15] particularly the specific pro-noradrenergic antidepressants such as desimipramine and reboxetine have been shown to inhibit CREB activity[43], whereas selective serotonin reuptake inhibitors (SSRI) induce an activation of CREB.
Positive_regulation (activation) of CREB associated with antidepressant and ssri
7) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.34 Pain Relevance 0.59
Western blots demonstrate a 1.9-fold increase in cyclic AMP response element binding protein (CREB) and a 2.4-fold increase phospho-CREB immunoreactivities in spinal cord homogenates from morphine tolerant animals.
Positive_regulation (increase) of CREB in spinal cord associated with morphine and spinal cord
8) Confidence 0.69 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10507546 Disease Relevance 0 Pain Relevance 0.79
Western blots demonstrate a 1.9-fold increase in cyclic AMP response element binding protein (CREB) and a 2.4-fold increase phospho-CREB immunoreactivities in spinal cord homogenates from morphine tolerant animals.
Positive_regulation (increase) of cyclic AMP response element binding protein in spinal cord associated with morphine and spinal cord
9) Confidence 0.69 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10507546 Disease Relevance 0 Pain Relevance 0.79
However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.
Positive_regulation (upregulation) of CREB associated with desipramine
10) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943827 Disease Relevance 0.10 Pain Relevance 0.87
These data are the first to demonstrate that CREB activation is upstream of BDNF mechanistically in response to antidepressant drug treatment.
Positive_regulation (activation) of CREB associated with antidepressant
11) Confidence 0.69 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943827 Disease Relevance 0.09 Pain Relevance 0.83
CREB is rapidly activated by phosphorylation of the serine residue 133 [10].
Positive_regulation (activated) of CREB
12) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.20 Pain Relevance 0.06
CREB activity is increased in ACC neurons by physiological stimulation as well as pathological injury [2,14,15].
Positive_regulation (increased) of CREB in ACC neurons associated with injury and anterior cingulate cortex
13) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1459854 Disease Relevance 0.61 Pain Relevance 0.41
Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord.
Positive_regulation (activation) of CREB in spinal cord associated with spinal cord
14) Confidence 0.68 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17692820 Disease Relevance 0.44 Pain Relevance 0.23
Such data suggest that immediately following drug intake, upregulation in accumbal CREB (or increased phosphorylation of CREB) may diminish the salience of further drug administration.
Positive_regulation (upregulation) of CREB
15) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.33 Pain Relevance 0.28
Drugs of abuse alter pCREB levels directly through kinase pathways, and CREB levels indirectly through gene expression systems; however, viral (HSV) overexpression systems increase CREB directly, without altering pCREB levels directly through endogenously occuring systems.
Positive_regulation (increase) of CREB associated with cold sores
16) Confidence 0.68 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.25 Pain Relevance 0.04
These results suggest that the endogenous opioid tone acting on mu-/delta-receptors tonically stimulate CREB activation in the brain.
Positive_regulation (activation) of CREB in brain associated with endogenous opioid
17) Confidence 0.66 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.07 Pain Relevance 0.87
While papaverine treatment reduced CREB protein levels in the hippocampus and striatum, fluoxetine increased CREB in the hippocampus.
Positive_regulation (increased) of CREB in striatum associated with hippocampus and fluoxetine
18) Confidence 0.64 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17913473 Disease Relevance 0.93 Pain Relevance 0.60
Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.
Positive_regulation (increased) of CREB
19) Confidence 0.61 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20164327 Disease Relevance 0.61 Pain Relevance 0.35
However, morphine-induced increases of phospho-CREB levels are seen in the VTA of wild-type mice but not CREBalphaDelta mutant mice.
Positive_regulation (increases) of phospho-CREB associated with ventral tegmentum and morphine
20) Confidence 0.61 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622103 Disease Relevance 0 Pain Relevance 0.74

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